Vaccines have had a profound impact on the management and prevention of infectious
disease. In addition, the development of vaccines against chronic diseases has attracted …

Clonal selection theory proposed that individual T cells are specific for a single peptide–
MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast …

The immune system can mount T cell responses against tumors; however, the antigen
specificities of tumor-infiltrating lymphocytes (TILs) are not well understood. We used yeast …

Adoptive transfer of T cells genetically modified to express a cancer-specific T-cell receptor
(TCR) has shown significant therapeutic potential for both hematological and solid tumors …

This review discusses peptide epitopes used as antigens in the development of vaccines in
clinical trials as well as future vaccine candidates. It covers peptides used in potential …

CD8+ T cells destroy insulin-producing pancreatic β cells in type 1 diabetes through HLA
class I–restricted presentation of self-antigens. Combinatorial peptide library screening was …

The naïve T‐cell repertoire is vast, containing millions of unique T‐cell receptor (TCR)
structures. Faced with such diversity, the mobilization of TCR structures from this enormous …

The cross-reactivity of T cells with pathogen-and self-derived peptides has been implicated
as a pathway involved in the development of autoimmunity. However, the mechanisms that …

Neoantigens are tumor-specific peptide sequences resulting from sources such as somatic
DNA mutations. Upon loading onto major histocompatibility complex (MHC) molecules, they …

Analysis of antigen‐specific T‐cell populations by flow cytometry with peptide–MHC (pMHC)
multimers is now commonplace. These reagents allow the tracking and phenotyping of T …