The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality

TH Karlsen, N Sheron, S Zelber-Sagi, P Carrieri… - The Lancet, 2022 - thelancet.com
Executive summary Liver diseases have become a major health threat across Europe, and
the face of European hepatology is changing due to the cure of viral hepatitis C and the …

Healthcare and socioeconomic costs of NAFLD: A global framework to navigate the uncertainties

AM Allen, JV Lazarus, ZM Younossi - Journal of hepatology, 2023 - Elsevier
Left unaddressed, non-alcoholic fatty liver disease (NAFLD) will continue to have substantial
health, economic and social implications. To address the challenge, a paradigm shift is …

The global impact of hepatitis B vaccination on hepatocellular carcinoma

JE Flores, AJ Thompson, M Ryan, J Howell - Vaccines, 2022 - mdpi.com
Over 1.5 million preventable new hepatitis B infections continue to occur each year and
there are an estimated 296 million people living with chronic hepatitis B infection worldwide …

Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019

PA Cortesi, C Fornari, S Conti, IC Antonazzo… - The Lancet Public …, 2023 - thelancet.com
Summary Background In 2016, the World Health Assembly adopted the resolution to
eliminate viral hepatitis by 2030. This study aims to provide an overview of the burdens of …

Serum biomarkers for the prediction of hepatocellular carcinoma

JD Debes, PA Romagnoli, J Prieto, M Arrese… - Cancers, 2021 - mdpi.com
Hepatocellular carcinoma (HCC) is a leading cause of global cancer death. Major etiologies
of HCC relate to chronic viral infections as well as metabolic conditions. The survival rate of …

Pathway to global elimination of hepatitis B: HBV cure is just the first step

J Howell, C Seaman, J Wallace, Y Xiao, N Scott… - Hepatology, 2023 - journals.lww.com
Hepatitis B (HBV) is a major cause of global morbidity and mortality, and the leading cause
of liver cancer worldwide. Significant advances have recently been made toward the …

Mitochondrial dysfunction and chronic liver disease

C Zhang, Y Zhao, M Yu, J Qin, B Ye… - Current issues in molecular …, 2022 - mdpi.com
Mitochondria are generally considered the powerhouse of the cell, a small subcellular
organelle that produces most of the cellular energy in the form of adenosine triphosphate …

[HTML][HTML] Viral hepatitis in 2021: The challenges remaining and how we should tackle them

R Dunn, A Wetten, S McPherson… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Viral hepatitis results in 1.4 million deaths annually. The World Health Organization (WHO)
set an ambitious target to eliminate viral hepatitis by 2030, but significant challenges remain …

Circulating microRNAs (miR‐16, miR‐22, miR‐122) expression and early diagnosis of hepatocellular carcinoma

Y Fang, D Yan, L Wang, J Zhang… - Journal of clinical …, 2022 - Wiley Online Library
Abstract Purpose Circulating microRNA (miRNA) has been reported to have diagnostic
value in multiple tumors. To identify serum miRNAs for early diagnosis of hepatocellular …

HCC biomarkers–state of the old and outlook to future promising biomarkers and their potential in everyday clinical practice

S Schlosser, D Tümen, B Volz, K Neumeyer… - Frontiers in …, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common and deadly tumors worldwide.
Management of HCC depends on reliable biomarkers for screening, diagnosis, and …