α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …

Abstract α-Synuclein is an abundant neuronal protein which localizes predominantly to
presynaptic terminals, and is strongly linked genetically and pathologically to Parkinson's …

At present, when a clinical diagnosis of Parkinson's disease (PD) is made, serious damage
has already been done to nerve cells of the substantia nigra pars compacta. The diagnosis …

Accumulation of the neuronal presynaptic protein alpha-synuclein within proteinaceous
inclusions represents the key histophathological hallmark of a spectrum of …

Increasing evidence suggests that neurodegenerative disorders share a common
pathogenic feature: the presence of deposits of misfolded proteins with altered …

Synucleins are small, soluble proteins expressed primarily in neural tissues and certain
tumors. The family includes three known proteins: α‐synuclein, β‐synuclein, and γ …

While the etiology of Parkinson′ s disease remains largely elusive, there is accumulating
evidence suggesting that mitochondrial dysfunction occurs prior to the onset of symptoms in …

Abstract The proteins of the 14-3-3 family are universal adapters participating in multiple
processes running in the cell. We describe the structure, isoform composition, and …

α-Synuclein, a major constituent of Lewy bodies (LBs), has been implicated to play a critical
role in the pathogenesis of Parkinson's disease (PD), although the physiological function of …

Denaturation and aggregation of proteins are reactions that are relevant to functional
applications of proteins in foods. Depending on concentration, ionic strength, and pH …