The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

Mitochondria serve as a hub for a multitude of vital cellular processes. To ensure an efficient
deployment of mitochondrial tasks, organelle homeostasis needs to be preserved …

Cellular exposure to ionizing radiation leads to oxidizing events that alter atomic structure
through direct interactions of radiation with target macromolecules or via products of water …

Mutations in the human mitochondrial genome are known to cause an array of diverse
disorders, most of which are maternally inherited, and all of which are associated with …

A large amount of the longevity-modulating genes discovered during the last two decades
are highly conserved during evolution from yeast and invertebrates to mammals. Many …

Rapamycin consistently increases longevity in mice although the mechanism of action of this
drug is unknown. In the present investigation we studied the effect of rapamycin on …

Mitochondria play a wide diversity of roles in cell physiology and have a key functional
implication in cell bioenergetics and biology of free radicals. As the main cellular source of …

Background All complex life on Earth is eukaryotic. All eukaryotic cells share a common
ancestor that arose just once in four billion years of evolution. Prokaryotes show no …

The transfer of mitochondrial DNA into the nuclear genomes of eukaryotes (Numts) has
been linked to lifespan in nonhuman species and recently demonstrated to occur in rare …

Patients receiving brain radiotherapy may suffer acute or chronic side effects. Ionizing
radiation induces the production of intracellular reactive oxygen species and pro …