Recent clinical trials using antibodies with low toxicity and high efficiency have raised
expectations for the development of next-generation protein therapeutics. However, the …

The emergence of egg allergy has had both industrial and clinical implications. In
industrialized countries, egg allergy accounts for one of the most prevalent food …

Clefts on protein surfaces are avoided by antigen-combining sites of conventional
antibodies, in contrast to heavy-chain antibodies (HCAbs) of camelids that seem to be …

Evolutionary advances are often fueled by unanticipated innovation. Directed evolution of a
computationally designed enzyme suggests that pronounced molecular changes can also …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

Herein we present COCOMAPS, a novel tool for analyzing, visualizing and comparing the
interface in protein–protein and protein–nucleic acids complexes. COCOMAPS combines …

We have assembled a nonredundant set of 144 protein–protein complexes that have high‐
resolution structures available for both the complexes and their unbound components, and …

Antibodies developed for research and clinical applications may exhibit suboptimal stability,
expressibility, or affinity. Existing optimization strategies focus on surface mutations …

Rational engineering methods can be applied with reasonable success to optimize
physicochemical characteristics of proteins, in particular, antibodies. Here, we describe a …

With the increased global awareness and rise in food allergies, a multifold interest in food
allergens is evident. The presence of undeclared food allergens results in expensive food …