Confronting COVID-19-associated cough and the post-COVID syndrome: role of viral neurotropism, neuroinflammation, and neuroimmune responses

WJ Song, CKM Hui, JH Hull, SS Birring… - The Lancet …, 2021 - thelancet.com
Cough is one of the most common presenting symptoms of COVID-19, along with fever and
loss of taste and smell. Cough can persist for weeks or months after SARS-CoV-2 infection …

Neuroinflammation and central sensitization in chronic and widespread pain

RR Ji, A Nackley, Y Huh, N Terrando… - …, 2018 - pmc.ncbi.nlm.nih.gov
Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic
plasticity and increased neuronal responsiveness in central pain pathways after painful …

Pain regulation by non-neuronal cells and inflammation

RR Ji, A Chamessian, YQ Zhang - Science, 2016 - science.org
Acute pain is protective and a cardinal feature of inflammation. Chronic pain after arthritis,
nerve injury, cancer, and chemotherapy is associated with chronic neuroinflammation, a …

Mechanisms and therapeutic relevance of neuro-immune communication

SS Chavan, VA Pavlov, KJ Tracey - Immunity, 2017 - cell.com
Active research at the frontiers of immunology and neuroscience has identified multiple
points of interaction and communication between the immune system and the nervous …

Molecular and functional neuroscience in immunity

VA Pavlov, SS Chavan, KJ Tracey - Annual review of …, 2018 - annualreviews.org
The nervous system regulates immunity and inflammation. The molecular detection of
pathogen fragments, cytokines, and other immune molecules by sensory neurons generates …

Inflammation in the pathophysiology of neuropathic pain

C Sommer, M Leinders, N Üçeyler - Pain, 2018 - journals.lww.com
2. Methods This is a narrative review based on the authors' research and on that of groups
working in the same area. Given the vast amount of data in the field, it is not possible to …

Quantitative and stoichiometric analysis of the microRNA content of exosomes

JR Chevillet, Q Kang, IK Ruf… - Proceedings of the …, 2014 - National Acad Sciences
Exosomes have been proposed as vehicles for microRNA (miRNA)-based intercellular
communication and a source of miRNA biomarkers in bodily fluids. Although exosome …

Emerging targets in neuroinflammation-driven chronic pain

RR Ji, ZZ Xu, YJ Gao - Nature reviews Drug discovery, 2014 - nature.com
Current analgesics predominately modulate pain transduction and transmission in neurons
and have limited success in controlling disease progression. Accumulating evidence …

Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease

D Santovito, C Weber - Nature Reviews Cardiology, 2022 - nature.com
Research showing that microRNAs (miRNAs) are versatile regulators of gene expression
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …

Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain

PCT Tang, JYF Chung, J Liao, MKK Chan… - Science …, 2022 - science.org
Tumor innervation is a common phenomenon with unknown mechanism. Here, we
discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de …