Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic plasticity and increased neuronal responsiveness in central pain pathways after painful …
Acute pain is protective and a cardinal feature of inflammation. Chronic pain after arthritis, nerve injury, cancer, and chemotherapy is associated with chronic neuroinflammation, a …
Active research at the frontiers of immunology and neuroscience has identified multiple points of interaction and communication between the immune system and the nervous …
The nervous system regulates immunity and inflammation. The molecular detection of pathogen fragments, cytokines, and other immune molecules by sensory neurons generates …
C Sommer, M Leinders, N Üçeyler - Pain, 2018 - journals.lww.com
2. Methods This is a narrative review based on the authors' research and on that of groups working in the same area. Given the vast amount of data in the field, it is not possible to …
JR Chevillet, Q Kang, IK Ruf… - Proceedings of the …, 2014 - National Acad Sciences
Exosomes have been proposed as vehicles for microRNA (miRNA)-based intercellular communication and a source of miRNA biomarkers in bodily fluids. Although exosome …
RR Ji, ZZ Xu, YJ Gao - Nature reviews Drug discovery, 2014 - nature.com
Current analgesics predominately modulate pain transduction and transmission in neurons and have limited success in controlling disease progression. Accumulating evidence …
Research showing that microRNAs (miRNAs) are versatile regulators of gene expression has instigated tremendous interest in cardiovascular research. The overwhelming majority of …
Tumor innervation is a common phenomenon with unknown mechanism. Here, we discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de …