Proteins are the main targets of most drugs; however, system-wide methods to monitor
protein activity and function are still underused in drug discovery. Novel biochemical …

Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …

Decidual remodelling of midluteal endometrium leads to a short implantation window after
which the uterine mucosa either breaks down or is transformed into a robust matrix that …

Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …

Cells have a remarkable ability to synthesize large amounts of protein in a very short period
of time. Under these conditions, many hydrophobic surfaces on proteins may be transiently …

Hepatitis C virus (HCV) is a major cause of liver disease, but therapeutic options are limited
and there are no prevention strategies. Viral entry is the first step of infection and requires …

Cellular senescence is a stress response mechanism ensuring homeostasis. Its temporal
activation during embryonic development or normal adult life is linked with beneficial …

Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

We generated cell lines resistant to BRAF inhibitors and show that the EGF receptor (EGFR)–
SRC family kinase (SFK)–STAT3 signaling pathway was upregulated in these cells. In …

Almost all human cancers display dysregulated expression and/or function of one or more
receptor tyrosine kinases (RTKs). The strong causative association between altered RTK …