Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …

Abstract 'Glomerulonephritis'(GN) is a term used to describe a group of heterogeneous
immune-mediated disorders characterized by inflammation of the filtration units of the kidney …

Le syndrome néphrotique à lésions glomérulaires minimes (LGM) et la hyalinose
segmentaire et focale (HSF) primitive sont deux pathologies glomérulaires qui entrainent un …

Accumulating evidence indicates that inflammatory and immunologic processes play a
significant role in the development and progression of glomerular diseases. Podocytes, the …

The pathogenetic mechanisms underlying the onset and the post-transplant recurrence of
primary focal segmental glomerulosclerosis (FSGS) are complex and remain yet to be fully …

Idiopathic nephrotic syndrome is the most common glomerular disease in children.
Corticosteroids are the cornerstone of its treatment, and steroid response is the main …

Focal segmental glomerulosclerosis (FSGS) is a common glomerular disorder that manifests
clinically with the nephrotic syndrome and has a propensity to recur following kidney …

The therapeutic efficacy of B-cell depletion by anti-CD20 treatment in pediatric and, more
recently, in adult idiopathic nephrotic syndrome patients suggests a key role of B cells in the …

Rituximab is an established therapy in children with idiopathic nephrotic syndrome to
sustain short-to medium-term disease remission and avoid steroid toxicities. Recent trials …

The efficacy of the B cell-targeting drug rituximab (RTX) in childhood idiopathic nephrotic
syndrome (INS) suggests that B cells may be implicated in disease pathogenesis. However …