General guidelines for the molecular basis of functional variation are presented while
focused on the rotating circular genetic code and allowable exchanges that make it resistant …

Abstract Background Eradication of Helicobacter pylori provides the most effective treatment
for gastroduodenal diseases caused by H. pylori infection. Clarithromycin, a member of the …

Filamentous fungi are widely exploited in food industry due to their abilities to secrete large
amounts of enzymes and metabolites. The recent availability of fungal genome sequences …

Background Codon bias is believed to play an important role in the control of gene
expression. In Escherichia coli, some rare codons, which can limit the expression level of …

One of the central issues of evolutionary genomics is to find out the adaptive strategies of
microorganisms to stabilize nucleic acid molecules under high temperature. Thermal …

Sequence dependence of solvent accessibility in globular and membrane proteins is well
established. However, this important structural property has been poorly investigated in …

A comprehensive survey was carried out to identify orthologs of proteins from 526 bacterial
and archaeal genomes, with the aim of investigating the mechanism of thermal adaptation of …

By analyzing the predicted gene expression levels of 33 prokaryotes with living temperature
span from< 10° C to> 100° C, a universal positive correlation was found between the …

Positive correlation between gene expression and synonymous codon usage bias is well
documented in the literature. However, in the present study of Vibrio cholerae genome, we …

There are two main approaches to assess the robustness of genetic codes and coding
sequences. The statistical approach is based on empirical estimates of probabilities …