Staphylococcus aureus is one of the most frequent worldwide causes of morbidity and
mortality due to an infectious agent. This pathogen can cause a wide variety of diseases …

Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome
drives release of the proinflammatory cytokines interleukin (IL)-1β and IL-18 and induces …

Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of severe and often
fatal infections. MRSA epidemics have occurred in waves, whereby a previously successful …

Clinical severity of Staphylococcus aureus respiratory infection correlates with alpha toxin
(AT) expression. AT activates the NLRP3 inflammasome; deletion of Nlrp3, or AT …

Rationale: Infections caused by multidrug-resistant bacteria are a major clinical challenge.
Phage therapy is a promising alternative antibacterial strategy. Objectives: To evaluate the …

ABSTRACT Introduction Methicillin-resistant Staphylococcus aureus (MRSA) is a
widespread pathogen, often causing recurrent and deadly infections in the hospital and …

Diverse post-translational modifications have been shown to play important roles in
regulating protein function in eukaryotes. By contrast, the roles of post-translational …

The current epidemic proportions of infections caused by Staphylococcus aureus strains and
especially by methicillin-resistant S. aureus (MRSA) are one of today's many threats to …

Novel Staphylococcus aureus clones continue to emerge that cause infections in otherwise
healthy people. One example is the sequence type (ST) 398 lineage, which we show here is …

Among clinically relevant lineages of Staphylococcus aureus, the lineage or clonal complex
398 (CC398) is of particular interest. Strains from this lineage were only described as …