Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …

The development of therapeutics for cytomegalovirus (CMV) infections, while progressing,
has not matched the pace of new treatments of human immunodeficiency virus (HIV) …

Mycobacterium tuberculosis (Mtb) employs plethora of mechanisms to hijack the host
defence machinery for its successful survival, proliferation and persistence. Here, we show …

Enzymes from pathogens often modulate host protein post-translational modifications
(PTMs), facilitating survival and proliferation of pathogens. Shigella virulence factors IpaJ …

Histone modifications control numerous processes in eukaryotes, including inflammation.
Some bacterial pathogens alter the activity or expression of host-derived factors, including …

SIRT2, a cytoplasmic member of the Sirtuin family, has important roles in immunity and
inflammation. However, its function in regulating the response to DNA virus infection …

Increasing evidence highlights the role of bacteria in promoting tumorigenesis. The
underlying mechanisms may be diverse and remain poorly understood. Here, we report that …

Salmonella Typhi (S. Typhi), the invasive typhoidal serovar of Salmonella enterica that
causes typhoid fever in humans, is a severe threat to global health. It is one of the major …

By modifying the host cell transcription programme, pathogenic bacteria disrupt a wide
range of cellular processes and take control of the host's immune system. Conversely, by …

Nicotinamide adenine dinucleotide (NAD+) is a major cofactor in redox reactions in all life-
forms. A stable level of NAD+ is vital to ensure cellular homeostasis. Some pathogens can …