The formation of blood clots—thrombosis—at sites of atherosclerotic plaque rupture is a
major clinical problem despite ongoing improvements in antithrombotic therapy. Progress in …

This report is the continuation of two earlier reports that defined human arterial intima and
precursors of advanced atherosclerotic lesions in humans. This report describes the …

Objectives: We examined mortality in relation to coronary artery disease (CAD) as assessed
by≥ 64-detector row coronary computed tomography angiography (CCTA). Background …

Coronary atherosclerosis is by far the most frequent cause of ischemic heart disease, and
plaque disruption with superimposed thrombosis is the main cause of the acute coronary …

Objectives: In a computed tomographic (CT) angiography study, we identified the
characteristics of atherosclerotic lesions that were associated with subsequent development …

The majority of patients with acute coronary syndromes (ACS) present with unstable angina,
acute myocardial infarction, and sudden coronary death. The most common cause of …

Background Coronary thrombosis has been reported to occur most frequently in lipid-rich
plaques with rupture of a thin fibrous cap and contact of the thrombus with a pool of …

Background Androgen deprivation therapy (ADT) is associated with increased
cardiovascular morbidity. Objective To determine whether cardiovascular morbidity differs …

Background—Subclinical episodes of plaque disruption followed by healing are considered
a mechanism of increased plaque burden. Detailed pathological studies of healed ruptures …

Paul Dudley White was an astute observer of ischemic heart disease who emphasized the
unity of acute myocardial infarction and chronic exertional angina as facets of the clinical …