In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Endothelial to mesenchymal transition (EndMT) is a complex biological process that gives
rise to cells with multipotent potential. EndMT is essential for the formation of the …

When cancer metastasizes to bone, considerable pain and deregulated bone remodelling
occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and …

1164 Circulation Research April 12, 2019 blocked the EndMT and fibrotic markers and
reduced migration of TGFβ-treated valve endothelial cells. CD45 is not normally expressed …

Bone metastasis is a major cause of morbidity in persons with cancer. Complications include
pain, impaired mobility, pathological fracture, spinal cord compression, cranial nerve …

Oncosomes are tumor-derived microvesicles that transmit signaling complexes between cell
and tissue compartments. Herein, we show that amoeboid tumor cells export large (1-to 10 …

Increasing evidence indicates that tumor–stromal cell interactions have a crucial role in
tumor initiation and progression. These interactions modify cellular compartments, leading to …

There is increasing evidence that a variety of cancers arise from transformation of normal
stem cells to cancer stem cells (CSCs). CSCs are thought to sustain cancer progression …

The vascular endothelium is a dynamic cellular “organ” that controls passage of nutrients
into tissues, maintains the flow of blood, and regulates the trafficking of leukocytes. In …

The concept of antiangiogenic therapy in cancer treatment has led to the approval of
different agents, most of them targeting the well known vascular endothelial growth factor …