Chondroitin sulfate (CS) is a member of glycosaminoglycans (GAGs) and has critical
physiological functions. CS is widely applied in medical and clinical fields. Currently, the …

Sulfotransferases (STs) catalyze the transfer reaction of the sulfate group from the ubiquitous
donor 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to an acceptor group of …

Sequences and structures of all P-loop-fold proteins were compared with the aim of
reconstructing the principal events in the evolution of P-loop-containing kinases. It is shown …

Post-translational tyrosine O-sulfation of proteins was first observed by Bettelheim in bovine
fibrinopeptide B in 1954 (1). In the 1960s several small peptides including gastrin …

Sulfonation as one of the most important modification reactions in nature is essential for
many biological macromolecules to function. Development of green sulfonate group donor …

Tyrosine sulfation is a post-translational modification of many secreted and membrane-
bound proteins. Its biological roles have been unclear. Recent work has implicated tyrosine …

Macular corneal dystrophy (MCD; MIM 217800) is an autosomal recessive hereditary
disease in which progressive punctate opacities in the cornea result in bilateral loss of …

We report the cloning and partial characterization of the fourth member of the vertebrate
heparan sulfate/heparin: GlcNAc N-deacetylase/GlcNN-sulfotransferase family, which we …

3-O-Sulfated glucosaminyl residues are rare constituents of heparan sulfate and are
essential for the activity of anticoagulant heparan sulfate. Cellular production of the critical …

Various kinds of primary metabolisms in plants are modulated through sulfate metabolism,
and sulfotransferases (SOTs), which are engaged in sulfur metabolism, catalyze sulfonation …