[HTML][HTML] Body fatness associations with cancer: evidence from recent epidemiological studies and future directions

SC Larsson, N Spyrou, CS Mantzoros - Metabolism, 2022 - Elsevier
This narrative review highlights current evidence linking greater body fatness to risk of
various cancers, with focus on evidence from recent large cohort studies and pooled …

Systematic review of Mendelian randomization studies on risk of cancer

G Markozannes, A Kanellopoulou, O Dimopoulou… - BMC medicine, 2022 - Springer
Background We aimed to map and describe the current state of Mendelian randomization
(MR) literature on cancer risk and to identify associations supported by robust evidence …

Exploring diseases/traits and blood proteins causally related to expression of ACE2, the putative receptor of SARS-CoV-2: a Mendelian randomization analysis …

S Rao, A Lau, HC So - Diabetes care, 2020 - Am Diabetes Assoc
OBJECTIVE COVID-19 has become a major public health problem. There is good evidence
that ACE2 is a receptor for SARS-CoV-2, and high expression of ACE2 may increase …

Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study

M Vithayathil, P Carter, S Kar, AM Mason… - PLoS …, 2021 - journals.plos.org
Background Evidence for the impact of body size and composition on cancer risk is limited.
This mendelian randomisation (MR) study investigates evidence supporting causal …

Associations between genetically predicted levels of blood metabolites and pancreatic cancer risk

H Zhong, S Liu, J Zhu, L Wu - International Journal of Cancer, 2023 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid
malignancies, which is featured by systematic metabolism. Thus, a better understanding of …

[HTML][HTML] The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic …

D Campa, M Gentiluomo, A Stein, MN Aoki… - Critical reviews in …, 2023 - Elsevier
Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of
risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of …

The role of Mendelian randomization studies in deciphering the effect of obesity on cancer

Z Fang, M Song, DH Lee… - JNCI: Journal of the …, 2022 - academic.oup.com
Associations of obesity have been established for at least 11 cancer sites in observational
studies, though some questions remain as to causality, strength of associations, and timing …

The timing of adiposity and changes in the life course on the risk of cancer

Z Fang, EL Giovannucci - Cancer and Metastasis Reviews, 2022 - Springer
Excess body weight has been established as a risk factor for at least twelve cancer sites,
though questions remain as to the timing of associations for adiposity and cancer risk …

Germline genetic variability in pancreatic cancer risk and prognosis

M Gentiluomo, F Canzian, A Nicolini… - Seminars in cancer …, 2022 - Elsevier
Pancreatic cancer (PC), particularly its most common form, pancreatic ductal
adenocarcinoma (PDAC), is relatively rare but highly lethal. Knowledge about PC risk …

Mendelian randomisation study of the effects of known and putative risk factors on pancreatic cancer

Y Lu, M Gentiluomo, J Lorenzo-Bermejo… - Journal of medical …, 2020 - jmg.bmj.com
Background Observational studies have reported multiple risk factors for pancreatic ductal
adenocarcinoma (PDAC). Some are well established, like tobacco smoking, alcohol …