Neurodegenerative causes of blindness and deafness possess a major challenge in their
clinical management as proper treatment guidelines have not yet been found. Brain-derived …

Hearing loss, or deafness, affects 360 million people worldwide of which about 32 million
are children. Deafness is irreversible when it involves sensory hair cell death because the …

Cochlear implants electrically stimulate spiral ganglion neurons (SGNs) in order to provide
speech cues to severe-profoundly deaf patients. In normal hearing cochleae the SGNs …

Abstract Treatment with neurotrophins prevents degeneration of spiral ganglion cells (SGCs)
after severe hair cell loss. In a previous study we demonstrated a long-lasting effect with …

Successful cochlear implant performance requires adequate responsiveness of the auditory
nerve to prolonged pulsatile electrical stimulation. Degeneration of the auditory nerve as a …

Hearing loss in patients with vestibular schwannoma (VS) is commonly attributed to
mechanical compression of the auditory nerve, though recent studies suggest that this …

Sensorineural hearing loss is commonly caused by damage to cochlear sensory hair cells.
Coinciding with hair cell degeneration, the peripheral fibres of type I spiral ganglion neurons …

Severe damage to the organ of Corti leads to degeneration of the spiral ganglion cells
(SGCs) which form the auditory nerve. This degeneration starts at the level of synaptic …

Damage to and loss of the organ of Corti leads to secondary degeneration of the spiral
ganglion cell (SGC) somata of the auditory nerve. Extensively examined in animal models …

The auditory nerve typically degenerates following loss of cochlear hair cells or synapses. In
the case of hair cell loss neural degeneration hinders restoration of hearing through a …