Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …

Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in double-
stranded RNA. This A-to-I editing occurs not only in protein-coding regions of mRNAs, but …

Abstract Adenosine-to-inosine (A-to-I) RNA editing is a conserved post-transcriptional
mechanism mediated by ADAR enzymes that diversifies the transcriptome by altering …

Excitotoxicity is classically defined as the neuronal damage caused by the excessive
release of glutamate, and subsequent activation of excitatory plasma membrane receptors …

One of the most prevalent forms of post-transcritpional RNA modification is the conversion of
adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The …

Post-transcriptional modifications have been recently expanded with the addition of RNA
editing, which is predominantly mediated by adenosine and cytidine deaminases acting on …

RNA editing is a cellular process that precisely alters nucleotide sequences, thus regulating
gene expression and generating protein diversity. Over 60% of human transcripts undergo …

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are comprised of
different combinations of GluA1–GluA4 (also known asGluR1–GluR4 and GluR-A to GluR …

We review the structures and functions of ADARs and their involvements in human diseases.
ADAR1 is widely expressed, particularly in the myeloid component of the blood system, and …

Post-transcriptional RNA modification by adenosine to inosine (A-to-I) editing expands the
functional output of many important neuronally expressed genes. The mechanism provides …