Abstract Ossovskaya, Valeria S., and Nigel W. Bunnett. Protease-Activated Receptors:
Contribution to Physiology and Disease. Physiol Rev 84: 579–621, 2004; 10.1152/physrev …

Serine proteinases such as thrombin, mast cell tryptase, trypsin, or cathepsin G, for example,
are highly active mediators with diverse biological activities. So far, proteinases have been …

Proteinases like thrombin, trypsin and tissue kallikreins are now known to regulate cell
signaling by cleaving and activating a novel family of G‐protein‐coupled proteinase …

Human airway smooth muscle (ASM) has several properties and functions that contribute to
asthma pathogenesis, and increasing attention is being paid to its synthetic capabilities …

Airway smooth muscle (ASM) extends from the trachea throughout the bronchial tree to the
terminal bronchioles. In utero, spontaneous phasic contraction of fetal ASM is critical for …

The survival and proliferation of pathogenic Leptospira within a host are complex
phenomena that require careful consideration. The ErpY-like lipoprotein, found on the outer …

Protease‐activated receptors (PARs) are a novel family of G protein‐coupled receptors.
Signalling through PARs typically involves the cleavage of an extracellular region of the …

Airway remodelling is a feature of chronic asthma comprising smooth muscle hypertrophy
and deposition of extracellular matrix (ECM) proteins. Matrix metalloproteinases (MMPs) …

Protease-activated receptors (PAR), which are G protein-coupled receptors, have 4
members, PAR-1 to PAR-4. PARs are activated by proteolysis of a peptide bond at the N …

Idiopathic pulmonary fibrosis (IPF) is a severe, progressive and irreversible lung disease
constantly associated with a major vascular remodeling process. Endothelial colony-forming …