The current obesity pandemic results from a physiological imbalance in which energy intake
chronically exceeds energy expenditure (EE), and prevention and treatment strategies …

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for
the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR …

Key points Mice are commonly housed at room temperatures below their thermoneutral
zone meaning they are exposed to chronic thermal stress. Endurance exercise induces …

In hepatocytes, peroxisome proliferator-activated receptor α (PPARα) orchestrates a
genomic and metabolic response required for homeostasis during fasting. This includes the …

Objectives Heat-sensory neurons from the dorsal root ganglia (DRG) play a pivotal role in
detecting the cutaneous temperature and transmission of external signals to the brain …

Beta-3 adrenergic receptor activation via exercise or CL316, 243 (CL) induces white
adipose tissue (WAT) browning, improves glucose tolerance, and reduces visceral adiposity …

Objective The sympathetic nervous system (SNS) is a key regulator of the metabolic and
endocrine functions of adipose tissue. Increased SNS outflow promotes fat mobilization …

Olanzapine is a second-generation antipsychotic (SGA) used in the treatment of
schizophrenia and a number of off-label conditions. Although effective in reducing …

Key points Mammals defend against cold‐induced reductions in body temperature through
both shivering and non‐shivering thermogenesis. The activation of non‐shivering …

Abstract Objective T-box 1 (TBX1) has been identified as a genetic marker of beige adipose
tissue. TBX1 is a mesodermal development transcription factor essential for tissue patterning …