Physiology and role of irisin in glucose homeostasis

N Perakakis, GA Triantafyllou… - Nature reviews …, 2017 - nature.com
Irisin is a myokine that leads to increased energy expenditure by stimulating the'browning'of
white adipose tissue. In the first description of this hormone, increased levels of circulating …

Irisin in metabolic diseases

SA Polyzos, AD Anastasilakis, ZA Efstathiadou… - Endocrine, 2018 - Springer
Introduction Irisin is a myokine/adipokine induced by the exercise in mice and humans,
which is proposed to induce “browning” of white adipose tissue, its primary target, thus …

Irisin ameliorates neuroinflammation and neuronal apoptosis through integrin αVβ5/AMPK signaling pathway after intracerebral hemorrhage in mice

Y Wang, M Tian, J Tan, X Pei, C Lu, Y Xin… - Journal of …, 2022 - Springer
Background Neuroinflammation is a crucial factor in the development of secondary brain
injury after intracerebral hemorrhage (ICH). Irisin is a newly identified myokine that confers …

Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes

TY Liu, CX Shi, R Gao, HJ Sun, XQ Xiong… - Clinical …, 2015 - portlandpress.com
Increased glucose production and reduced hepatic glycogen storage contribute to metabolic
abnormalities in diabetes. Irisin, a newly identified myokine, induces the browning of white …

Three new players in energy regulation: preptin, adropin and irisin

S Aydin - Peptides, 2014 - Elsevier
Homeostasis of energy is regulated by genetic factors, food intake, and energy expenditure.
When energy input is greater than expenditure, the balance is positive, which can lead to …

The novel exercise-induced hormone irisin protects against neuronal injury via activation of the Akt and ERK1/2 signaling pathways and contributes to the …

DJ Li, YH Li, HB Yuan, LF Qu, P Wang - Metabolism, 2017 - Elsevier
Background Irisin is a novel exercise-induced myokine involved in the regulation of adipose
browning and thermogenesis. In this study, we investigated the potential role of irisin in …

Role of oxidative stress and antioxidants in daily nutrition and human health

G Bjørklund, S Chirumbolo - Nutrition, 2017 - Elsevier
Diet is a complex process that we are just beginning to fully understand. We need to develop
a deeper comprehension of metabolism, energy balance, the molecular pathways involved …

FNDC5/Irisin system in neuroinflammation and neurodegenerative diseases: update and novel perspective

P Pignataro, M Dicarlo, R Zerlotin, C Zecca… - International Journal of …, 2021 - mdpi.com
Irisin, the circulating peptide originating from fibronectin type III domain-containing protein 5
(FNDC5), is mainly expressed by muscle fibers under peroxisome proliferator-activated …

A comprehensive immunohistochemical examination of the distribution of the fat-burning protein irisin in biological tissues

S Aydin, T Kuloglu, S Aydin, M Kalayci, M Yilmaz… - Peptides, 2014 - Elsevier
Irisin was first identified in skeletal muscle cells, but its precise location has not yet been
demonstrated, and there is limited information about irisin protein in other human and rat …

Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism

J Zhang, P Valverde, X Zhu, D Murray, Y Wu, L Yu… - Bone research, 2017 - nature.com
Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III
domain-containing 5 (FNDC5) protein. Once released to circulation upon exercise or cold …