Engineered in vitro disease models
The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …
human disease or to develop new and improved therapies or diagnostics. Although great …
Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience
The scarcity of live human brain cells for experimental access has for a long time limited our
ability to study complex human neurological disorders and elucidate basic neuroscientific …
ability to study complex human neurological disorders and elucidate basic neuroscientific …
Genomic patterns of de novo mutation in simplex autism
To further our understanding of the genetic etiology of autism, we generated and analyzed
genome sequence data from 516 idiopathic autism families (2,064 individuals). This …
genome sequence data from 516 idiopathic autism families (2,064 individuals). This …
[引用][C] Consciousness and the Brain: Deciphering How the Brain Codes Our Thoughts
S Dehaene - 2014 - books.google.com
WINNER OF THE 2014 BRAIN PRIZE From the acclaimed author of Reading in the Brain
and How We Learn, a breathtaking look at the new science that can track consciousness …
and How We Learn, a breathtaking look at the new science that can track consciousness …
[HTML][HTML] Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism
Genetic studies have identified dozens of autism spectrum disorder (ASD) susceptibility
genes, raising two critical questions:(1) do these genetic loci converge on specific biological …
genes, raising two critical questions:(1) do these genetic loci converge on specific biological …
Mapping of neuronal and glial primary cilia contactome and connectome in the human cerebral cortex
JY Wu, SJ Cho, K Descant, PH Li, A Shapson-Coe… - Neuron, 2024 - cell.com
Primary cilia act as antenna receivers of environmental signals and enable effective
neuronal or glial responses. Disruption of their function is associated with circuit disorders …
neuronal or glial responses. Disruption of their function is associated with circuit disorders …
Modeling human cortical development in vitro using induced pluripotent stem cells
J Mariani, MV Simonini, D Palejev… - Proceedings of the …, 2012 - National Acad Sciences
Human induced pluripotent stem cells (hiPSCs) are emerging as a tool for understanding
human brain development at cellular, molecular, and genomic levels. Here we show that …
human brain development at cellular, molecular, and genomic levels. Here we show that …
Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders
In a research environment dominated by reductionist approaches to brain disease
mechanisms, gene network analysis provides a complementary framework in which to tackle …
mechanisms, gene network analysis provides a complementary framework in which to tackle …
Changing conceptualizations of regression: What prospective studies reveal about the onset of autism spectrum disorder
Until the last decade, studies of the timing of early symptom emergence in autism spectrum
disorder (ASD) relied upon retrospective methods. Recent investigations, however, are …
disorder (ASD) relied upon retrospective methods. Recent investigations, however, are …
Human-specific transcriptional networks in the brain
G Konopka, T Friedrich, J Davis-Turak, K Winden… - Neuron, 2012 - cell.com
Understanding human-specific patterns of brain gene expression and regulation can
provide key insights into human brain evolution and speciation. Here, we use next …
provide key insights into human brain evolution and speciation. Here, we use next …