Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (KATP) channel
activity provides a unique link between cellular energetics and electrical excitability. Over …

ATP-sensitive potassium (KATP) channels are present in many tissues, including pancreatic
islet cells, heart, skeletal muscle, vascular smooth muscle, and brain, in which they couple …

The appropriate secretion of insulin from pancreatic β-cells is critically important to the
maintenance of energy homeostasis. The β-cells must sense and respond suitably to …

Nutrient homeostasis is known to be regulated by pancreatic islet tissue. The function of islet
β-cells is controlled by a glucose sensor that operates at physiological glucose …

Sulphonylureas have been used for over 50 years to enhance insulin secretion in patients
with Type II (non-insulin-dependent) diabetes mellitus but their therapeutic target was not …

In many excitable cells, KATP channels respond to intracellular adenosine nucleotides: ATP
inhibits while ADP activates. We present two structures of the human pancreatic KATP …