Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature
myeloid cells with immunosuppressive effects, which undergo massive expansion during …

Hypoxia is prevalent in human tumours and contributes to microenvironments that shape
cancer evolution and adversely affect therapeutic outcomes. Historically, two different …

Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …

The success of atezolizumab plus bevacizumab treatment contributed to a shift in systemic
therapies for hepatocellular carcinoma (HCC) towards combinations that include cancer …

CC chemokines, a subfamily of 27 chemotactic cytokines, are a component of intercellular
communication, which is crucial for the functioning of the tumor microenvironment. Although …

Hypoxia, low oxygen (O2) level, is a hallmark of solid cancers, especially hepatocellular
carcinoma (HCC), one of the most common and fatal cancers worldwide. Hypoxia …

Epithelial–mesenchymal transition (EMT) has been shown to play a critical role in tumor
development from initiation to metastasis. EMT could be regarded as a continuum, with …

Summary Background The IMpower150 trial showed significant improvements in
progression-free and overall survival with atezolizumab plus bevacizumab plus carboplatin …

Despite the remarkable success of immune checkpoint inhibitors (ICIs) in melanoma
treatment, resistance to them remains a substantial clinical challenge. Myeloid-derived …