Thrombosis and von Willebrand factor

M Shahidi - Thrombosis and Embolism: from Research to Clinical …, 2017 - Springer
One of the key players in both hemostasis and thrombosis is von Willebrand factor (vWF),
which demonstrates a duality between these two processes. Thrombus is structured by …

Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical …

F Gijsen, Y Katagiri, P Barlis, C Bourantas… - European heart …, 2019 - academic.oup.com
Expert recommendations on the assessment of wall shear stress in human coronary arteries:
existing methodologies, technical considerations, and clinical applications | European Heart …

[HTML][HTML] Transport physics and biorheology in the setting of hemostasis and thrombosis

LF Brass, SL Diamond - Journal of Thrombosis and Haemostasis, 2016 - Elsevier
The biophysics of blood flow can dictate the function of molecules and cells in the
vasculature with consequent effects on hemostasis, thrombosis, embolism, and fibrinolysis …

Fluid dynamics in the HeartMate 3: influence of the artificial pulse feature and residual cardiac pulsation

L Wiegmann, B Thamsen, D De Zélicourt… - Artificial …, 2019 - Wiley Online Library
Ventricular assist devices (VADs), among which the HeartMate 3 (HM3) is the latest clinically
approved representative, are often the therapy of choice for patients with end‐stage heart …

Shear stress‐induced total blood trauma in multiple species

CHH Chan, IL Pieper, CR Robinson… - Artificial …, 2017 - Wiley Online Library
The common complications in heart failure patients with implanted ventricular assist devices
(VADs) include hemolysis, thrombosis, and bleeding. These are linked to shear stress …

Coagulation factor levels and underlying thrombin generation patterns in adult extracorporeal membrane oxygenation patients

M Mazzeffi, E Strauss, M Meyer, S Hasan… - Anesthesia & …, 2019 - journals.lww.com
BACKGROUND: There is a paucity of data on the underlying procoagulant–anticoagulant
balance during extracorporeal membrane oxygenation (ECMO). We hypothesized that adult …

Current understanding of leukocyte phenotypic and functional modulation during extracorporeal membrane oxygenation: a narrative review

KK Ki, JE Millar, D Langguth, MR Passmore… - Frontiers in …, 2021 - frontiersin.org
A plethora of leukocyte modulations have been reported in critically ill patients. Critical
illnesses such as acute respiratory distress syndrome and cardiogenic shock, which …

Application of microfluidic chip technology to study the inhibitory effect of tetramethylpyrazine on platelet aggregation, activation, and phosphatidylserine exposure …

T Zhang, L Liu, X Huang, X Gao, D Chen… - Blood Coagulation & …, 2023 - journals.lww.com
Methods In this study, we developed a microfluidic chip model that can mimic normal
arteries and stenotic arterial vessels, and studied the inhibitory effects of TMA on platelet …

Von Willebrand factor concentrate administration for acquired von Willebrand syndrome-related bleeding during adult extracorporeal membrane oxygenation

M Mazzeffi, A Bathula, A Tabatabai, J Menaker… - Journal of cardiothoracic …, 2021 - Elsevier
Objective To review the use of Von Willebrand Factor (VWF) concentrate for treatment of
acquired Von Willebrand syndrome (VWS)-related bleeding in adult extracorporeal …

Effect of pulsatility on shear‐induced extensional behavior of Von Willebrand factor

Y Wang, KT Nguyen, E Ismail, L Donoghue… - Artificial …, 2022 - Wiley Online Library
Background Patients with continuous flow ventricular assist devices (CF‐VADs) are at high
risk for non‐surgical bleeding, speculated to associate with the loss of pulsatility following …