Poxviruses, of which vaccinia virus is the prototype, are a large family of double-stranded
DNA viruses that replicate exclusively in the cytoplasm of infected cells. This physical and …

Many viruses that replicate in the cytoplasm compartmentalize their genome replication and
transcription in organelle-like structures that enhance replication efficiency and protection …

In 2022, a global outbreak of Mpox (formerly monkeypox) occurred in various countries
across Europe and America and rapidly spread to more than 100 countries and regions. The …

The actin and microtubule cytoskeleton play important roles in the life cycle of every virus.
During attachment, internalization, endocytosis, nuclear targeting, transcription, replication …

Poxviruses are large DNA viruses that include the causal agent of human smallpox and
vaccinia virus. Poxviruses replicate in cytoplasmic foci known as DNA factories. Here we …

The combination of cryo-microscopy and electron tomographic reconstruction has allowed
us to determine the structure of one of the more complex viruses, intracellular mature …

Incoming viral particles move from the cell surface to sites of viral transcription and
replication. By contrast, during assembly and egress, subviral nucleoprotein complexes and …

Microtubules (MTs) form a rapidly adaptable network of filaments that radiate throughout the
cell. These dynamic arrays facilitate a wide range of cellular processes, including the …

Virus replication can cause extensive rearrangement of host cell cytoskeletal and membrane
compartments leading to the “cytopathic effect” that has been the hallmark of virus infection …

Upon infection, virions or subviral nucleoprotein complexes are transported from the cell
surface to the site of viral transcription and replication. During viral egress, particles …