Role of inflammation in diabetic retinopathy

A Rübsam, S Parikh, PE Fort - International journal of molecular sciences, 2018 - mdpi.com
Diabetic retinopathy is a common complication of diabetes and remains the leading cause of
blindness among the working-age population. For decades, diabetic retinopathy was …

Angiogenesis and inflammation crosstalk in diabetic retinopathy

M Capitão, R Soares - Journal of cellular biochemistry, 2016 - Wiley Online Library
Diabetic retinopathy (DR) is one of the most prevalent microvascular complications of
diabetes and one of the most frequent causes of blindness in active age. Etiopathogenesis …

The eye and the heart

J Flammer, K Konieczka, RM Bruno… - European heart …, 2013 - academic.oup.com
The vasculature of the eye and the heart share several common characteristics. The easily
accessible vessels of the eye are therefore—to some extent—a window to the heart. There is …

Diabetic macular edema: pathogenesis and treatment

N Bhagat, RA Grigorian, A Tutela, MA Zarbin - Survey of ophthalmology, 2009 - Elsevier
Diabetic macular edema is a major cause of visual impairment. The pathogenesis of
macular edema appears to be multifactorial. Laser photocoagulation is the standard of care …

MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis

S Hiratsuka, K Nakamura, S Iwai, M Murakami, T Itoh… - Cancer cell, 2002 - cell.com
The molecular mechanism of tissue-specific metastasis in tumors endogenously expressing
members of the vascular endothelial growth factor (VEGF) family is not yet clear. Here we …

[HTML][HTML] Targeting inflammation in diabetes: Newer therapeutic options

NK Agrawal, S Kant - World journal of diabetes, 2014 - ncbi.nlm.nih.gov
Inflammation has been recognised to both decrease beta cell insulin secretion and increase
insulin resistance. Circulating cytokines can affect beta cell function directly leading to …

Diabetic retinopathy and inflammation: novel therapeutic targets

S Rangasamy, PG McGuire, A Das - Middle East African journal of …, 2012 - journals.lww.com
Most anti-vascular endothelial growth factor (VEGF) therapies in diabetic macular edema
are not as robust as in proliferative diabetic retinopathy. Although the VEGF appears to be a …

From oxidative stress to inflammation in the posterior ocular diseases: diagnosis and treatment

A Dammak, F Huete-Toral, C Carpena-Torres… - Pharmaceutics, 2021 - mdpi.com
Most irreversible blindness observed with glaucoma and retina-related ocular diseases,
including age-related macular degeneration and diabetic retinopathy, have their origin in the …

Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9

RA Kowluru, Q Zhong, JM Santos - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Diabetic retinopathy remains one of the most feared complications of diabetes.
Despite extensive research in the field, the molecular mechanism responsible for the …

Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress

RB Caldwell, M Bartoli, MA Behzadian… - Current drug …, 2005 - ingentaconnect.com
Retinal neovascularization and macular edema are central features of diabetic retinopathy,
a major cause of blindness in working age adults. The currently established treatment for …