Na+-dependent excitatory amino acid transporters (EAATs) are the major transport
mechanisms for extracellular glutamate removal in the central nervous system (CNS). The …

New Findings What is the topic of this review? This paper overviews the links between Ca2+
and Na+ signalling in various types of cells. What advances does it highlight? This paper …

Abstract Structure-dynamic analysis of archaeal NCX (NCX_Mj) provided new insights into
the underlying mechanisms of ion selectivity, ion-coupled alternating access, ion occlusion …

The plasma-membrane homeostasis Na+/Ca2+ exchangers (NCXs) mediate Ca2+
extrusion/entry to dynamically shape Ca2+ signaling/in biological systems ranging from …

Calcium is a well-studied ion that acts as a cofactor in several reactions and as intracellular
second messenger. It plays crucial roles in living cells by regulating several processes from …

The calcium carbonate skeletons of corals provide the underlying structure of coral reefs;
however, the cellular mechanisms responsible for coral calcification remain poorly …

Intracellular Ca2+ distribution is a tightly regulated process. Numerous Ca2+ chelating,
storage, and transport mechanisms are required to maintain normal cellular physiology …

Na+/Ca 2+ exchanger (NCX) proteins operate through the alternating access mechanism,
where the ion-binding pocket is exposed in succession either to the extracellular or the …

Abstract Cytosolic Ca2+ and Na+ allosterically regulate Na+/Ca2+ exchanger (NCX)
proteins to vary the NCX-mediated Ca2+ entry/exit rates in diverse cell types. To resolve the …

Abstract Prokaryotic and eukaryotic Na+/Ca 2+ exchangers (NCX) control Ca 2+
homeostasis. NCX orthologs exhibit up to 10 4-fold differences in their turnover rates (k cat) …