Present knowledge on peroxiredoxins is reviewed with special emphasis on catalytic
principles, specificities and biological function. Peroxiredoxins are low efficiency …

Trypanosomes and leishmania, the causative agents of several tropical diseases, possess a
unique redox metabolism which is based on trypanothione. The bis (glutathionyl) …

Significance: Oxidative stress is widely invoked in inflammation, aging, and complex
diseases. To avoid unwanted oxidations, the redox environment of cellular compartments …

Barley 2-cysteine peroxiredoxin (2-Cys Prx) was analyzed for peroxide reduction,
quaternary structure, thylakoid attachment, and function as well as in vivo occurrence of the …

The bis (glutathionyl) spermidine trypanothione exclusively occurs in parasitic protozoa of
the order Kinetoplastida, such as trypanosomes and leishmania, some of which are the …

Tryparedoxin peroxidase (TXNPx) of Trypanosomatidae is the terminal peroxidase of a
complex redox cascade that detoxifies hydroperoxides by NADPH (Nogoceke et al., Biol …

The history of free radical biochemistry is briefly reviewed in respect to major trend shifts
from the focus on radiation damage toward enzymology of radical production and removal …

Thioredoxin (TRX) family proteins are involved in various biologic processes by regulating
the response to oxidative stress. Nucleoredoxin (NRX), a relatively uncharacterized member …

Significance: Parasitic infections continue to be a major problem for global human health.
Vaccines are practically not available and chemotherapy is highly unsatisfactory. One …

Detoxification of hydroperoxides in trypanosomes is mediated by a series of linked redox
pathways that are dependent on the parasite-specific thiol trypanothione for reducing …