[HTML][HTML] Glucagon-like peptide 1 (GLP-1)
TD Müller, B Finan, SR Bloom, D D'Alessio… - Molecular …, 2019 - Elsevier
Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …
[HTML][HTML] From NASH to diabetes and from diabetes to NASH: mechanisms and treatment options
A Gastaldelli, K Cusi - JHEP reports, 2019 - Elsevier
The worldwide prevalence of non-alcoholic fatty liver disease (NAFLD) is estimated to have
reached 25% or more in adults. NAFLD is prevalent in obese individuals, but may also affect …
reached 25% or more in adults. NAFLD is prevalent in obese individuals, but may also affect …
Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables
E Ahlqvist, P Storm, A Käräjämäki… - The lancet Diabetes & …, 2018 - thelancet.com
Background Diabetes is presently classified into two main forms, type 1 and type 2 diabetes,
but type 2 diabetes in particular is highly heterogeneous. A refined classification could …
but type 2 diabetes in particular is highly heterogeneous. A refined classification could …
Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes
D Mansour Aly, OP Dwivedi, RB Prasad… - Nature …, 2021 - nature.com
Type 2 diabetes has been reproducibly clustered into five subtypes with different disease
progression and risk of complications; however, etiological differences are unknown. We …
progression and risk of complications; however, etiological differences are unknown. We …
Type 2 diabetes mellitus
RA DeFronzo, E Ferrannini, L Groop… - Nature reviews Disease …, 2015 - nature.com
Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to
the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular …
the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular …
[HTML][HTML] Diabetes mellitus: The epidemic of the century
AT Kharroubi, HM Darwish - World journal of diabetes, 2015 - ncbi.nlm.nih.gov
The epidemic nature of diabetes mellitus in different regions is reviewed. The Middle East
and North Africa region has the highest prevalence of diabetes in adults (10.9%) whereas …
and North Africa region has the highest prevalence of diabetes in adults (10.9%) whereas …
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance
Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the
mechanisms underlying this link remain obscure. Using an integrative genomic approach …
mechanisms underlying this link remain obscure. Using an integrative genomic approach …
A high-coverage genome sequence from an archaic Denisovan individual
We present a DNA library preparation method that has allowed us to reconstruct a high-
coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The …
coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The …
Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes
Genetic studies promise to provide insight into the molecular mechanisms underlying type 2
diabetes (T2D). Variants associated with T2D are often located in tissue-specific enhancer …
diabetes (T2D). Variants associated with T2D are often located in tissue-specific enhancer …
Genetics of type 2 diabetes—pitfalls and possibilities
Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between
genetic, epigenetic and environmental factors. While the major environmental factors, diet …
genetic, epigenetic and environmental factors. While the major environmental factors, diet …