Microbiome differential abundance analysis methods for two groups are well-established in
the literature. However, many microbiome studies involve more than two groups, sometimes …

As one reflects back through the past 50 years of scientific research, a significant
accomplishment was the advance into the genomic era. Basic research scientists have …

Motivation: An important feature of microbiome count data is the presence of a large number
of zeros. A common strategy to handle these excess zeros is to add a small number called …

Motivation: Multi-series time-course microarray experiments are useful approaches for
exploring biological processes. In this type of experiments, the researcher is frequently …

Motivation: Time series expression experiments are used to study a wide range of biological
systems. More than 80% of all time series expression datasets are short (8 time points or …

Context Medication and cognitive behavioral treatment are the best-established treatments
for social anxiety disorder, yet many individuals remain symptomatic after treatment …

Estrogens exert many important effects in bone, a tissue that contains both estrogen
receptors α and β (ERα and ERβ). To compare the actions of these receptors, we generated …

Objectives To identify and compare the gene expression profiles of actinic keratosis (AK)
and squamous cell carcinoma (SCC) and to further clarify critical genetic alterations in the …

Feature selection is an important topic in data mining, especially for high dimensional
datasets. Filtering techniques in particular have received much attention, but detailed …

An unprecedented interest in biomarker development has arisen from the increasing use of
genomic information and high-throughput technologies in the field of drug development …