Cardiac metabolism is vital for heart function. Given that cardiac contraction requires a
continuous supply of ATP in large quantities, the role of fuel metabolism in the heart has …

Western lifestyle contributes to an overt increase in the prevalence of metabolic anomalies
including diabetes mellitus (DM) and obesity. Prevalence of DM is rapidly growing …

Myocardial damage is the most serious pathological consequence of cardiovascular
diseases and an important reason for their high mortality. In recent years, because of the …

Metabolic syndrome is a complex metabolic disorder that often clinically manifests as
obesity, insulin resistance/diabetes, hyperlipidemia, and hypertension. With the …

Mitochondria sense both biochemical and energetic input in addition to communicating
signals regarding the energetic state of the cell. Increasingly, these signaling organelles are …

Alzheimer's disease (AD), an age-related neurodegenerative disorder, is currently incurable.
Imbalanced amyloid-beta (Aβ) generation and clearance are thought to play a pivotal role in …

Diabetic cardiomyopathy is a chronic cardiovascular complication caused by diabetes that is
characterized by changes in myocardial structure and function, ultimately leading to heart …

Regular exercise has both immediate and long-lasting benefits on cardiometabolic health,
and has been recommended as a cornerstone of treatment in the management of diabetes …

Exercise physiology has gained increasing interest due to its wide effects to promote health.
Recent years have seen a growth in this research field also due to the finding of several …

Sirtuins (SIRTs) are a nicotinic adenine dinucleotide (+)-dependent histone deacetylase that
regulates critical signaling pathways in prokaryotes and eukaryotes. Studies have identified …