The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …

Melanosomes are morphologically and functionally unique organelles within which melanin
pigments are synthesized and stored. Melanosomes share some characteristics with …

Phagosomal biogenesis is a fundamental biological process of particular significance for the
function of phagocytic and antigen-presenting cells. The precise mechanisms governing …

Vesicle transport is a fundamental mechanism of communication in the CNS. In this study we
characterized a novel type of vesicle released by murine brain microglial cells: microglial …

Melanosomes and premelanosomes are lysosome-related organelles with a unique
structure and cohort of resident proteins. We have positioned these organelles relative to …

Endolysosomal organelles play a key role in trafficking, breakdown and receptor-mediated
recycling of different macromolecules such as low-density lipoprotein (LDL)-cholesterol …

Rab5 regulates endocytic membrane traffic by specifically recruiting cytosolic effector
proteins to their site of action on early endosomal membranes. We have characterized a …

Recent data both from cell-free experiments and from cultured cells have shown that
lysosomes can fuse directly with late endosomes to form a hybrid organelle. This has a led …

In many cells endosomal vacuoles show clathrin coats of which the function is unknown.
Herein, we show that this coat is predominantly present on early endosomes and has a …

Lysosomes mediate hydrolase-catalyzed macromolecule degradation to produce building
block catabolites for reuse. Lysosome function requires an osmo-sensing machinery that …