Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's disease
DOT Alawode, AJ Heslegrave… - Journal of internal …, 2021 - Wiley Online Library
Alzheimer's disease (AD) is increasingly prevalent worldwide, and disease‐modifying
treatments may soon be at hand; hence, now, more than ever, there is a need to develop …
treatments may soon be at hand; hence, now, more than ever, there is a need to develop …
The potential of blood neurofilament light as a marker of neurodegeneration for Alzheimer's disease
Y Jung, JS Damoiseaux - Brain, 2024 - academic.oup.com
Over the past several years, there has been a surge in blood biomarker studies examining
the value of plasma or serum neurofilament light (NfL) as a biomarker of neurodegeneration …
the value of plasma or serum neurofilament light (NfL) as a biomarker of neurodegeneration …
Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease
Alzheimer's disease (AD) pathology develops many years before the onset of cognitive
symptoms. Two pathological processes—aggregation of the amyloid-β (Aβ) peptide into …
symptoms. Two pathological processes—aggregation of the amyloid-β (Aβ) peptide into …
Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN)
Abstract The Dominantly Inherited Alzheimer Network (DIAN) is an international
collaboration studying autosomal dominant Alzheimer disease (ADAD). ADAD arises from …
collaboration studying autosomal dominant Alzheimer disease (ADAD). ADAD arises from …
Bundle-specific associations between white matter microstructure and Aβ and tau pathology in preclinical Alzheimer's disease
Beta-amyloid (Aβ) and tau proteins, the pathological hallmarks of Alzheimer's disease (AD),
are believed to spread through connected regions of the brain. Combining diffusion imaging …
are believed to spread through connected regions of the brain. Combining diffusion imaging …
Significance of blood and cerebrospinal fluid biomarkers for Alzheimer's disease: sensitivity, specificity and potential for clinical use
C d'Abramo, L D'adamio, L Giliberto - Journal of Personalized Medicine, 2020 - mdpi.com
Alzheimer's disease (AD) is the most common type of dementia, affecting more than 5 million
Americans, with steadily increasing mortality and incredible socio-economic burden. Not …
Americans, with steadily increasing mortality and incredible socio-economic burden. Not …
Association of chronic kidney disease with plasma NfL and other biomarkers of neurodegeneration: the H70 birth cohort study in Gothenburg
A Dittrich, NJ Ashton, H Zetterberg, K Blennow… - Neurology, 2023 - AAN Enterprises
Background and Objectives Studies associate chronic kidney disease (CKD) with
neurodegeneration. This study investigated the relationship between kidney function, blood …
neurodegeneration. This study investigated the relationship between kidney function, blood …
Plasma NfL is associated with the APOE ε4 allele, brain imaging measurements of neurodegeneration, and lower recall memory scores in cognitively unimpaired late …
Abstract Background Plasma neurofilament light (NfL) is an indicator of neurodegeneration
and/or neuroaxonal injury in persons with Alzheimer's disease (AD) and a wide range of …
and/or neuroaxonal injury in persons with Alzheimer's disease (AD) and a wide range of …
High serum neurofilament associates with diffuse white matter damage in MS
M Saraste, S Bezukladova, M Matilainen… - Neurology …, 2020 - AAN Enterprises
Objective To evaluate to which extent serum neurofilament light chain (NfL) increase is
related to diffusion tensor imaging–MRI measurable diffuse normal-appearing white matter …
related to diffusion tensor imaging–MRI measurable diffuse normal-appearing white matter …
Neurofilaments–Small proteins of physiological significance and predictive power for future neurodegeneration and cognitive decline across the life span
Neurofilaments (NFs) are not only important for axonal integrity and nerve conduction in
large myelinated axons but they are also thought to be crucial for receptor and synaptic …
large myelinated axons but they are also thought to be crucial for receptor and synaptic …