Radiation response in the tumour microenvironment: predictive biomarkers and future perspectives

NM Byrne, P Tambe, JA Coulter - Journal of Personalized Medicine, 2021 - mdpi.com
Radiotherapy (RT) is a primary treatment modality for a number of cancers, offering
potentially curative outcomes. Despite its success, tumour cells can become resistant to RT …

MRI-based radiomic prognostic signature for locally advanced oral cavity squamous cell carcinoma: development, testing and comparison with genomic prognostic …

A Corti, L De Cecco, S Cavalieri, D Lenoci, F Pistore… - Biomarker …, 2023 - Springer
Background. At present, the prognostic prediction in advanced oral cavity squamous cell
carcinoma (OCSCC) is based on the tumor-node-metastasis (TNM) staging system, and the …

Clonal evolution of long-term expanding head and neck cancer organoid: Impact on treatment response for personalized therapeutic screening

SY Choi, J Shim, D Gu, SY Kim, HJ Kim, DY Shin… - Oral Oncology, 2023 - Elsevier
Objectives In biobanking based on patient-derived organoids (PDO), the genetic stability of
organoid lines is critical for the clinical relevance of PDO with parental tumors. However …

Molecular Biomarkers for Predicting Cancer Patient Radiosensitivity and Radiotoxicity in Clinical Practice

A Gkikoudi, SA Kalospyros, S Triantopoulou… - Applied Sciences, 2023 - mdpi.com
Radiotherapy (RT) is a major part of cancer treatment. The reported variability in patient
response to this modality can interfere with the continuation of best-possible care, promote …

Development of a prediction model for radiotherapy response among patients with head and neck squamous cell carcinoma based on the tumor immune …

GL Zhu, KB Yang, C Xu, RJ Feng, WF Li… - Cancer medicine, 2022 - Wiley Online Library
Introduction The immune system and hypoxia are major factors influencing radiosensitivity in
patients with different cancer types. This study aimed at developing a model to predict …

Prediction of radiosensitivity and radiocurability using a novel supervised artificial neural network

Z Zeng, M Luo, Y Li, J Li, Z Huang, Y Zeng, Y Yuan… - BMC cancer, 2022 - Springer
Background Radiotherapy has been widely used to treat various cancers, but its efficacy
depends on the individual involved. Traditional gene-based machine-learning models have …

[HTML][HTML] A novel 3D pillar/well array platform using patient-derived head and neck tumor to predict the individual radioresponse

DW Lee, SY Choi, SY Kim, HJ Kim, DY Shin… - Translational …, 2022 - Elsevier
Predicting individual radiotherapy (RT) response is valuable in managing head and neck
squamous cell carcinoma (HNSCC). We assessed the feasibility of our novel 3D culture …

[HTML][HTML] Predicting radiotherapy efficacy and prognosis in tongue squamous cell carcinoma through an in-depth analysis of a radiosensitivity gene signature

J Lai, H Yang, J Chen, S Chen… - Frontiers in Oncology, 2024 - pmc.ncbi.nlm.nih.gov
Background Tongue squamous cell carcinoma (TSCC) is a prevalent tumor that affects
many people worldwide. Radiotherapy is a common treatment option, but its efficacy varies …

An Ensemble Framework Integrating Whole Slide Pathological Images and miRNA Data to Predict Radiosensitivity of Breast Cancer Patients

C Dong, J Liu, W Yan, M Han, L Wu, J Xia… - … Conference on Intelligent …, 2022 - Springer
Breast cancer (BRCA) is the most primary cause of cancer death among women worldwide,
and radiotherapy (RT) is a common treatment for BRCA patients. However, not all BRCA …

Induced Cytotoxicity In Crebbp/Ep300Mut Head And Neck Squamous Cell Carcinoma

T Pamplin - 2022 - digitalcommons.library.tmc.edu
Background: Head and neck squamous cell carcinoma HNSCC is the most common
malignancy in the head and neck. Most cases are found in advanced stages and depending …