Beside the therapeutic improvement over first-generation antipsychotics, the fact that
prescription of atypical agents is also associated to the emergence of severe metabolic …

The atypical antipsychotics (AAPs) have been used as first-line drugs in psychiatric practice
for a wide range of psychotic disorders, including schizophrenia and bipolar mania. While …

ETHNOPHARMACOLOGICAL RELEVANCE: Rhizoma Coptidis (RC), a widely used
traditional Chinese medicine, has been used for the treatment of heat-clearing and …

Atypical antipsychotics now represent the mainstay of treatment for patients with
schizophrenia. Unfortunately, as a class they have also been associated with an increased …

Several clinical reports have demonstrated that most antipsychotics of the new generation,
but not the typical antipsychotic haloperidol, induce weight gain in schizophrenic patients …

Objectives: Persistent reports have linked atypical antipsychotics with diabetes, yet
causative mechanisms responsible for this linkage are unclear. Goals of this review are to …

Antipsychotic drugs (APDs), and the 'atypical'APDs in particular, are commonly associated
with metabolic side effects in humans. These include glucose dysregulation, insulin …

Rationale Some novel antipsychotics, including olanzapine, induce weight gain and
metabolic abnormalities, which represent the major adverse effects of these drugs. However …

We have established an animal model for olanzapine-induced body weight gain, and used it
to explore the relation between this weight gain, excessive food consumption, gross motor …

Excessive bodyweight gain was reported during the 1950s as an adverse effect of typical
antipsychotic drug treatment, but the magnitude of bodyweight gain was found to be higher …