Keloids constitute an abnormal fibroproliferative wound healing response in which raised
scar tissue grows excessively and invasively beyond the original wound borders. This …

Significance: When a cutaneous injury occurs, the wound heals via a dynamic series of
physiological events, including coagulation, granulation tissue formation, re …

Keloids are an excessive tissue response to dermal damage, characterized by uncontrolled
growth and a high recurrence rate after various treatments. Abnormalities with the …

Skin fibrosis is the excessive deposition of extracellular matrix in the dermis. Cutaneous
fibrosis can occur following tissue injury, including burns, trauma, and surgery, resulting in …

Significance: In adult mammals, spontaneous repair of a cutaneous wound occurs slowly
and leaves a scar with skin adnexa deficiencies. To accelerate cutaneous wound-healing …

Keloid is a disease in which fibroblasts abnormally proliferate and synthesize excessive
amounts of extracellular matrix, including collagen and fibronectin, during the healing …

Keloid is characterized by fibroblastic cell proliferation and abundant collagen synthesis.
Numerous studies have shown that the Wingless type (Wnt) signaling pathways play key …

Endothelial‐to‐mesenchymal transition is a phenotypic conversion characterized by down‐
regulation of vascular endothelial markers and the acquisition of a mesenchymal phenotype …

Wnt/β-catenin signaling plays important roles in cutaneous wound healing and dermal
fibrosis. However, its regulatory mechanism has not been fully elucidated, and a …

Abstract β-elemene, extracted from Rhizoma zedoariae, has been widely used as a
traditional medicine for its antitumor activity against a broad range of cancers. However, the …