Engineered bacterial membrane vesicles are promising carriers for vaccine design and tumor immunotherapy

Q Long, P Zheng, X Zheng, W Li, L Hua, Z Yang… - Advanced drug delivery …, 2022 - Elsevier
Bacterial membrane vesicles (BMVs) have emerged as novel and promising platforms for
the development of vaccines and immunotherapeutic strategies against infectious and …

Outer membrane vesicles as platform vaccine technology

L Van Der Pol, M Stork, P van der Ley - Biotechnology journal, 2015 - Wiley Online Library
Outer membrane vesicles (OMVs) are released spontaneously during growth by many Gram‐
negative bacteria. They present a range of surface antigens in a native conformation and …

Outer membrane vesicles (OMVs) produced by gram‐negative bacteria: structure, functions, biogenesis, and vaccine application

N Furuyama, MP Sircili - BioMed Research International, 2021 - Wiley Online Library
Gram‐negative bacteria produce outer membrane vesicles (OMVs) with 10 to 300 nm of
diameter. The contribution of OMVs to bacterial pathogenesis is a topic of great interest, and …

Peptide-based vaccines for tuberculosis

W Gong, C Pan, P Cheng, J Wang, G Zhao… - Frontiers in …, 2022 - frontiersin.org
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. As a
result of the coronavirus disease 2019 (COVID-19) pandemic, the global TB mortality rate in …

Outer membrane vesicle induction and isolation for vaccine development

MD Balhuizen, EJA Veldhuizen… - Frontiers in …, 2021 - frontiersin.org
Gram-negative bacteria release vesicular structures from their outer membrane, so called
outer membrane vesicles (OMVs). OMVs have a variety of functions such as waste disposal …

Helicobacter pylori Outer Membrane Vesicle Size Determines Their Mechanisms of Host Cell Entry and Protein Content

L Turner, NJ Bitto, DL Steer, C Lo, K D'Costa… - Frontiers in …, 2018 - frontiersin.org
Gram-negative pathogens ubiquitously shed outer membrane vesicles (OMVs) that play a
central role in initiating and regulating pathogenesis in the host. Due to their highly …

Bacterial outer membrane vesicles and vaccine applications

R Acevedo, S Fernández, C Zayas, A Acosta… - Frontiers in …, 2014 - frontiersin.org
Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years
ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit …

Drug and vaccine development for the treatment and prevention of urinary tract infections

VP O'brien, TJ Hannan, HV Nielsen… - Urinary Tract Infections …, 2017 - Wiley Online Library
Urinary tract infections (UTI) are one of the most common bacterial infections, with roughly
eleven‐million cases reported in the US each year that cost an estimated $5 billion annually …

Outer membrane vesicles for vaccination and targeted drug delivery

S Wang, J Gao, Z Wang - Wiley Interdisciplinary Reviews …, 2019 - Wiley Online Library
Extracellular vesicles (EVs) are cell membrane‐derived compartments that spontaneously
secrete from a wide range of cells and tissues. EVs have shown to be the carriers in …

Fantastic voyage: the journey of intestinal microbiota-derived microvesicles through the body

R Stentz, AL Carvalho, EJ Jones… - Biochemical Society …, 2018 - portlandpress.com
As part of their life cycle, Gram-negative bacteria produce and release microvesicles (outer
membrane vesicles, OMVs) consisting of spherical protrusions of the outer membrane that …