A systematic review of multimodal brain age studies: Uncovering a divergence between model accuracy and utility

RJ Jirsaraie, AJ Gorelik, MM Gatavins, DA Engemann… - Patterns, 2023 - cell.com
Brain aging is a complex, multifaceted process that can be challenging to model in ways that
are accurate and clinically useful. One of the most common approaches has been to apply …

Mind the gap: Performance metric evaluation in brain‐age prediction

AMG de Lange, M Anatürk, J Rokicki… - Human Brain …, 2022 - Wiley Online Library
Estimating age based on neuroimaging‐derived data has become a popular approach to
developing markers for brain integrity and health. While a variety of machine‐learning …

[HTML][HTML] Deep neural networks learn general and clinically relevant representations of the ageing brain

EH Leonardsen, H Peng, T Kaufmann, I Agartz… - NeuroImage, 2022 - Elsevier
The discrepancy between chronological age and the apparent age of the brain based on
neuroimaging data—the brain age delta—has emerged as a reliable marker of brain health …

Cardiometabolic risk factors associated with brain age and accelerated brain ageing

D Beck, AMG de Lange, ML Pedersen… - Human brain …, 2022 - Wiley Online Library
The structure and integrity of the ageing brain is interchangeably linked to physical health,
and cardiometabolic risk factors (CMRs) are associated with dementia and other brain …

Predicting chronological age from structural neuroimaging: The predictive analytics competition 2019

L Fisch, R Leenings, NR Winter, U Dannlowski… - Frontiers in …, 2021 - frontiersin.org
Though aging is ubiquitous, the rate at which age-associated biological changes in the brain
occur differs substantially between individuals. Building on this, the so-called brain-age …

Probing multiple algorithms to calculate brain age: Examining reliability, relations with demographics, and predictive power

E Bacas, I Kahhalé, PR Raamana… - Human Brain …, 2023 - Wiley Online Library
The calculation of so‐called “brain age” from structural MRIs has been an emerging
biomarker in aging research. Data suggests that discrepancies between chronological age …

Brain age has limited utility as a biomarker for capturing fluid cognition in older individuals

A Tetereva, N Pat - Elife, 2024 - elifesciences.org
One well-known biomarker candidate that supposedly helps capture fluid cognition is Brain
Age, or a predicted value based on machine-learning models built to predict chronological …

A growth chart of brain function from infancy to adolescence based on EEG

KK Iyer, JA Roberts, M Waak, SJ Vogrin, A Kevat… - …, 2024 - thelancet.com
Background In children, objective, quantitative tools that determine functional
neurodevelopment are scarce and rarely scalable for clinical use. Direct recordings of …

[HTML][HTML] NeuropsychBrainAge: A biomarker for conversion from mild cognitive impairment to Alzheimer's disease

JG Condado, JM Cortes… - … & Disease Monitoring, 2023 - ncbi.nlm.nih.gov
METHODS A linear regressor BrainAge model was trained on healthy controls using
neuropsychological tests and neuroimaging features separately. The BrainAge delta …

BrainAGE: Revisited and reframed machine learning workflow

P Kalc, R Dahnke, F Hoffstaedter, C Gaser… - 2024 - Wiley Online Library
Since the introduction of the BrainAGE method, novel machine learning methods for brain
age prediction have continued to emerge. The idea of estimating the chronological age from …