Cancer represents a pathological manifestation of uncontrolled cell division; therefore, it has
long been anticipated that our understanding of the basic principles of cell cycle control …

Over the past two decades there has been a great deal of interest in the development of
inhibitors of the cyclin-dependent kinases (CDKs). This attention initially stemmed from …

Reactive oxygen species (ROS) at the right concentration promote cell proliferation in cell
culture, stem cells, and model organisms. However, the mystery of how ROS signaling is …

Purpose: Cyclin-dependent kinase (CDK) 4/6 drives cell proliferation in estrogen receptor–
positive (ER+) breast cancer. This single-arm phase II neoadjuvant trial (NeoPalAna) …

Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent
kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as …

Research of the past view years expanded our understanding of the various physiological
functions the cell-fate determining transcription factor SOX2 exerts in ontogenesis …

Mitogen-dependent progression through the first gap phase (G1) and initiation of DNA
synthesis (S phase) during the mammalian cell division cycle are cooperatively regulated by …

Purpose: Despite significant benefit for other cancer subtypes, immune checkpoint blockade
(ICB) therapy has not yet been shown to significantly improve outcomes for men with …

Hepatitis C virus (HCV) is a major cause of liver disease, but therapeutic options are limited
and there are no prevention strategies. Viral entry is the first step of infection and requires …

▪ Abstract Cyclin-dependent kinases (Cdks) play a well-established role in the regulation of
the eukaryotic cell division cycle and have also been implicated in the control of gene …