Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications
MO Goodarzi - The lancet Diabetes & endocrinology, 2018 - thelancet.com
Genome-wide association studies (GWAS) for BMI, waist-to-hip ratio, and other adiposity
traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although …
traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although …
Genome-wide association studies of cancer: current insights and future perspectives
Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
Diagnosis of obesity and use of obesity biomarkers in science and clinical medicine
K Nimptsch, S Konigorski, T Pischon - Metabolism, 2019 - Elsevier
The global epidemic of obesity is a major public health problem today. Obesity increases the
risk of many chronic diseases, such as type 2 diabetes, coronary heart disease, and certain …
risk of many chronic diseases, such as type 2 diabetes, coronary heart disease, and certain …
GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer
Genetic studies have examined body-shape measures adjusted for body mass index (BMI),
while allometric indices are additionally adjusted for height. We performed the first genome …
while allometric indices are additionally adjusted for height. We performed the first genome …
Causal relationships between obesity and the leading causes of death in women and men
JC Censin, SAE Peters, J Bovijn, T Ferreira… - PLoS …, 2019 - journals.plos.org
Obesity traits are causally implicated with risk of cardiometabolic diseases. It remains
unclear whether there are similar causal effects of obesity traits on other non-communicable …
unclear whether there are similar causal effects of obesity traits on other non-communicable …
Adiposity and gastrointestinal cancers: epidemiology, mechanisms and future directions
Excess adiposity is a risk factor for several cancers of the gastrointestinal system, specifically
oesophageal adenocarcinoma and colorectal, small intestine, pancreatic, liver, gallbladder …
oesophageal adenocarcinoma and colorectal, small intestine, pancreatic, liver, gallbladder …
Methodological approaches, challenges, and opportunities in the application of Mendelian randomisation to lifecourse epidemiology: A systematic literature review
Diseases diagnosed in adulthood may have antecedents throughout (including prenatal)
life. Gaining a better understanding of how exposures at different stages in the lifecourse …
life. Gaining a better understanding of how exposures at different stages in the lifecourse …
Systematic review of Mendelian randomization studies on risk of cancer
G Markozannes, A Kanellopoulou, O Dimopoulou… - BMC medicine, 2022 - Springer
Background We aimed to map and describe the current state of Mendelian randomization
(MR) literature on cancer risk and to identify associations supported by robust evidence …
(MR) literature on cancer risk and to identify associations supported by robust evidence …
Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation
Background: Some individuals living with obesity may be relatively metabolically healthy,
whilst others suffer from multiple conditions that may be linked to adverse metabolic effects …
whilst others suffer from multiple conditions that may be linked to adverse metabolic effects …
Maternal obesity, pregnancy weight gain, and birth weight and risk of colorectal cancer
Objective Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide.
Obesity is a well-established risk factor for CRC, and fetal or developmental origins of …
Obesity is a well-established risk factor for CRC, and fetal or developmental origins of …