We examine here several diseases that are associated with inappropriate activation of the
chemokine network. Detailed comment has been restricted to pathological states for which …

Although initially considered merely “scavenger cells” that participate in immunologic
responses only after B and T lymphocytes have performed their biological tasks, more recent …

Eosinophilic pneumonias (EP) encompass a wide spectrum of lung diseases characterized
by peripheral blood eosinophilia (> 1× 109 eosinophils/l) and/or alveolar eosinophilia (> …

Idiopathic chronic eosinophilic pneumonia is a rare disorder of unknown cause with
nonspecific respiratory and systemic symptoms but rather characteristic peripheral alveolar …

This review starts with discussions of several infectious causes of eosinophilic pneumonia,
which are almost exclusively parasitic in nature. Pulmonary infections due specifically to …

Eosinophilic chronic rhinosinusitis (ECRS) is a refractory airway disease accompanied by
eosinophilic inflammation, the mechanisms of which are unknown. We recently found that …

Background Chemokine receptors (CR) play an important role in T cell migration, but their
contribution to lung trafficking is unclear. Objective We hypothesized that if a particular CR …

Because the pathogenesis of acute respiratory distress syndrome (ARDS) induced by
influenza virus infection remains unknown, we can only improve on existing therapeutic …

Background Excessive eosinophil airway infiltration is a clinically critical condition in some
cases. Eosinophilic pneumonia (EP) is a pulmonary condition involving eosinophil …

Macrophage inflammatory protein (MIP)-1 α and MIP-1 β are two CC chemokines that
induce lymphocyte migration. MIP-1 α preferentially mediates chemotaxis of CD8 rather than …