Animals transmit not only DNA but also other molecules, such as RNA, proteins and
metabolites, to their progeny via gametes. It is currently unclear to what extent these …

Histone lysine methylation has emerged as a critical player in the regulation of gene
expression, cell cycle, genome stability, and nuclear architecture. Over the past decade, a …

Histone side chains are post-translationally modified at multiple sites, including at Lys36 on
histone H3 (H3K36). Several enzymes from yeast and humans, including the …

Chromatin modifiers regulate lifespan in several organisms, raising the question of whether
changes in chromatin states in the parental generation could be incompletely …

The factors that sequester transcriptionally repressed heterochromatin at the nuclear
periphery are currently unknown. In a genome-wide RNAi screen, we found that depletion of …

Non-membrane-bound organelles such as nucleoli, processing bodies, Cajal bodies and
germ granules form by the spontaneous self-assembly of specific proteins and RNAs. How …

SET domain-containing proteins belong to a group of enzymes named after a common
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …

Much attention has been given to the idea of transgenerational epigenetic inheritance, but
fundamental questions remain regarding how much takes place and the impact that this …

The molecular biological field of epigenetics has recently attracted attention not only in
biology, but also in the broader scientific community and the popular press. Commentators …

It is textbook knowledge that inheritance of traits is governed by genetics, and that the
epigenetic modifications an organism acquires are largely reset between generations …