New insights into acute pancreatitis
PJ Lee, GI Papachristou - Nature reviews Gastroenterology & …, 2019 - nature.com
The incidence of acute pancreatitis continues to increase worldwide, and it is one of the
most common gastrointestinal causes for hospital admission in the USA. In the past decade …
most common gastrointestinal causes for hospital admission in the USA. In the past decade …
Extracellular matrix structure
Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins …
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins …
Genetics, cell biology, and pathophysiology of pancreatitis
Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …
pancreatic genetics has made rapid progress. The identification of mutations in genes …
[HTML][HTML] Cathepsin B-mediated activation of trypsinogen in endocytosing macrophages increases severity of pancreatitis in mice
Background & Aims Acute pancreatitis is characterized by premature intracellular activation
of digestive proteases within pancreatic acini and a consecutive systemic inflammatory …
of digestive proteases within pancreatic acini and a consecutive systemic inflammatory …
Role of lysosomes in physiological activities, diseases, and therapy
Z Zhang, P Yue, T Lu, Y Wang, Y Wei, X Wei - Journal of hematology & …, 2021 - Springer
Long known as digestive organelles, lysosomes have now emerged as multifaceted centers
responsible for degradation, nutrient sensing, and immunity. Growing evidence also …
responsible for degradation, nutrient sensing, and immunity. Growing evidence also …
Specialized roles for cysteine cathepsins in health and disease
J Reiser, B Adair, T Reinheckel - The Journal of clinical …, 2010 - Am Soc Clin Investig
Cathepsins were originally identified as proteases that act in the lysosome. Recent work has
uncovered nontraditional roles for cathepsins in the extracellular space as well as in the …
uncovered nontraditional roles for cathepsins in the extracellular space as well as in the …
Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer
Inflammation and autophagy are cellular defense mechanisms. When these processes are
deregulated (deficient or overactivated) they produce pathologic effects, such as oxidative …
deregulated (deficient or overactivated) they produce pathologic effects, such as oxidative …
Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis
BACKGROUND & AIMS: The role of trypsinogen activation in the pathogenesis of acute
pancreatitis (AP) has not been clearly established. METHODS: We generated and …
pancreatitis (AP) has not been clearly established. METHODS: We generated and …
[HTML][HTML] Cysteine cathepsins: A long and winding road towards clinics
M Biasizzo, U Javoršek, E Vidak, M Zarić… - Molecular Aspects of …, 2022 - Elsevier
Biomedical research often focuses on properties that differentiate between diseased and
healthy tissue; one of the current focuses is elevated expression and altered localisation of …
healthy tissue; one of the current focuses is elevated expression and altered localisation of …
The gut microbiome in patients with chronic pancreatitis is characterized by significant dysbiosis and overgrowth by opportunistic pathogens
METHODS: Patients with clinical and imaging evidence of CP (n= 51) were prospectively
recruited and compared with twice the number of nonpancreatic disease controls matched …
recruited and compared with twice the number of nonpancreatic disease controls matched …