A brief introduction to chemical reaction optimization
From the start of a synthetic chemist's training, experiments are conducted based on recipes
from textbooks and manuscripts that achieve clean reaction outcomes, allowing the scientist …
from textbooks and manuscripts that achieve clean reaction outcomes, allowing the scientist …
Quality-by-design in hot melt extrusion based amorphous solid dispersions: An industrial perspective on product development
An industrially feasible approach to overcome the solubility and bioavailability limitations of
poorly soluble active pharmaceutical ingredients is the development of amorphous solid …
poorly soluble active pharmaceutical ingredients is the development of amorphous solid …
Application of graphical optimization, desirability, and multiple response functions in the extraction of food bioactive compounds
ID Boateng - Food Engineering Reviews, 2023 - Springer
Currently, statistical experimental design is employed as a quality control method to produce
excellent products at the lowest possible cost in food processing, speeding up the process of …
excellent products at the lowest possible cost in food processing, speeding up the process of …
Design of experiment (DoE) as a quality by design (QbD) tool to optimise formulations of lipid nanoparticles for nose-to-brain drug delivery
AC Correia, JN Moreira, JM Sousa Lobo… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction The nose-to-brain route has been widely investigated to improve drug targeting
to the central nervous system (CNS), where lipid nanoparticles (solid lipid nanoparticles …
to the central nervous system (CNS), where lipid nanoparticles (solid lipid nanoparticles …
Biosolids-derived biochar enhances the bioremediation of diesel-contaminated soil
Biochar, a low-cost carbonaceous product, is gaining relevance in the remediation of
hydrocarbon-contaminated soil. Current literature has shown that biochar studies have been …
hydrocarbon-contaminated soil. Current literature has shown that biochar studies have been …
Pathological and therapeutic significance of tumor-derived extracellular vesicles in cancer cell migration and metastasis
GL Liguori, V Kralj-Iglič - Cancers, 2023 - mdpi.com
Simple Summary Cancer metastasis accounts for almost 90% of cancer deaths worldwide.
The efficiency of current surgical, radiotherapeutic, and chemotherapeutic approaches is …
The efficiency of current surgical, radiotherapeutic, and chemotherapeutic approaches is …
Loteprednol-loaded nanoformulations for corneal delivery by quality-by-design concepts: optimization, characterization, and anti-inflammatory activity
Loteprednol etabonate (LE) is a topical corticosteroid that uses inflammatory conditions of
the eye. It has a low ocular bioavailability and side effects such as corneal disorder, eye …
the eye. It has a low ocular bioavailability and side effects such as corneal disorder, eye …
Development, optimization, and assessment of losartan nano-bilosomes to mitigate diabetes-induced microvascular complications in Sprague Dawley rats
Losartan has a significant renal protection effect in type 2 diabetic patients. It was loaded
into bilosomes to overcome its low oral bioavailability and improve its renal protective …
into bilosomes to overcome its low oral bioavailability and improve its renal protective …
Prediction and design of cyclodextrin inclusion complexes formation via machine learning-based strategies
This study reports a machine-learning (ML) method to develop multi-purpose prediction
strategies for the formation of cyclodextrin inclusion complexes (ICs) in aqueous solutions. A …
strategies for the formation of cyclodextrin inclusion complexes (ICs) in aqueous solutions. A …
Hot melt extrusion processing parameters optimization
The aim of this study was to demonstrate the impact of processing parameters of the hot-melt
extrusion (HME) on the pharmaceutical formulation properties. Carbamazepine (CBZ) was …
extrusion (HME) on the pharmaceutical formulation properties. Carbamazepine (CBZ) was …