Pannexins, large non-gap junction super family exists in vertebrates, play multiple roles in
different cellular functions through their ATP release. Panx1-mediated adenosine 5 …

Purinergic signaling encompasses the cycle of adenosine 5′ triphosphate (ATP) release
and its metabolism into nucleotide and nucleoside derivatives, the direct release of …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly rampaged
worldwide, causing a pandemic of coronavirus disease (COVID-19), but the biology of SARS …

The permeability of large cations through the P2X pore has remained arguably the most
controversial and complicated topic in P2X-related research, with the emergence of …

Dendritic spines are the postsynaptic targets of excitatory synaptic inputs that undergo
extensive proliferation and maturation during the first postnatal month in mice. However, our …

Cellular communication through gap junctions and hemichannels formed by connexins and
through channels made by pannexins allows for metabolic cooperation and control of …

Pannexin 1 (Panx1) is involved in the spinal central sensitization process in rats with
neuropathic pain, but its interaction with well-known, pain-related, ligand-dependent …

The integration of neurons into networks relies on the formation of dendritic spines. These
specialized structures arise from dynamic filopodia-like dendritic protrusions. It was recently …

Ethnopharmacological relevance Diabetic peripheral neuropathy (DPN) is a common
complication of diabetes mellitus, mainly manifested as paresthesia. Tangzu granule (TZG) …

Multiple Sklerose ist eine chronisch entzündliche Erkrankung des Gehirns und des
Rückenmarks, die durch lokale Infiltration zu Schäden an Myelin und Axonen führt. Bisher …