Neural circuits are assembled with remarkable precision during embryonic development,
and the selectivity inherent in their formation helps to define the behavioural repertoire of the …

Neurobiologists have long sought to understand how circuits in the nervous system are
organized to generate the precise neural outputs that underlie particular behaviours. The …

The extent to which low‐frequency (minor allele frequency (MAF) between 1–5%) and rare
(MAF≤ 1%) variants contribute to complex traits and disease in the general population is …

Animals generate movement by engaging spinal circuits that direct precise sequences of
muscle contraction, but the identity and organizational logic of local interneurons that lie at …

The spinal cord of vertebrate animals is comprised of intrinsic circuits that are capable of
sensing the environment and generating complex motor behaviors. There are two major …

Homeobox genes play fundamental roles in development. They can be subdivided into
several subfamilies, one of which is the LIM-homeobox subfamily. The primary structure of …

The generation of distinct classes of neurons at defined positions is a fundamental step in
the development of the vertebrate central nervous system. Recent work has begun to reveal …

Spinal interneurons help to coordinate motor behavior. During spinal cord development,
distinct classes of interneurons are generated from progenitor cells located at different …

Reciprocal activation of flexor and extensor muscles constitutes the fundamental mechanism
that tetrapod vertebrates use for locomotion and limb-driven reflex behaviors. This aspect of …

Induction of the floor plate at the ventral midline of the neural tube is one of the earliest
events in the establishment of dorsoventral (d/v) polarity in the vertebrate central nervous …