Signaling pathways in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma

K Maslenkina, L Mikhaleva, M Naumenko… - International Journal of …, 2023 - mdpi.com
Barrett's esophagus (BE) is a premalignant lesion that can develop into esophageal
adenocarcinoma (EAC). The development of Barrett's esophagus is caused by biliary reflux …

Single cell transcriptional zonation of human psoriasis skin identifies an alternative immunoregulatory axis conducted by skin resident cells

Y Gao, X Yao, Y Zhai, L Li, H Li, X Sun, P Yu… - Cell death & …, 2021 - nature.com
Psoriasis is the most common skin disease in adults. Current experimental and clinical
evidences suggested the infiltrating immune cells could target local skin cells and thus …

[图书][B] Gut: The Inside Story of Our Body's Most Underrated Organ (Revised Edition)

G Enders - 2018 - books.google.com
AN INSTANT NEW YORK TIMES BESTSELLER AS SEEN ON NETFLIX'S HACK YOUR
HEALTH: THE SECRETS OF YOUR GUT “Everything you ever wanted to know about the gut …

The metaplastic mosaic of Barrett's oesophagus

S Biswas, M Quante, S Leedham, M Jansen - Virchows Archiv, 2018 - Springer
Barrett's oesophagus surveillance biopsies represent a significant share of the daily
workload for a busy histopathology department. Given the emphasis on endoscopic …

Proton pump inhibitor use may not prevent high‐grade dysplasia and oesophageal adenocarcinoma in Barrett's oesophagus: a nationwide study of 9883 patients

F Hvid‐Jensen, L Pedersen… - Alimentary …, 2014 - Wiley Online Library
Background Proton pump inhibitors (PPI) may potentially modify and decrease the risk for
development of oesophageal adenocarcinoma in Barrett's oesophagus (BO). Aim To …

Expression of human skin-specific genes defined by transcriptomics and antibody-based profiling

PHD Edqvist, L Fagerberg… - … of Histochemistry & …, 2015 - journals.sagepub.com
To increase our understanding of skin, it is important to define the molecular constituents of
the cell types and epidermal layers that signify normal skin. We have combined a genome …

Rat reflux model of esophageal cancer and its implication in human disease

CL Greene, SG Worrell, TR DeMeester - Annals of Surgery, 2015 - journals.lww.com
Objectives: The epidemiologic shift in esophageal cancer from squamous cell carcinoma to
esophageal adenocarcinoma coincided with popularization of proton pump inhibitors and …

Embryological signaling pathways in Barrett's metaplasia development and malignant transformation; mechanisms and therapeutic opportunities

K Pavlov, C Meijer, A van den Berg, FTM Peters… - Critical reviews in …, 2014 - Elsevier
Barrett's metaplasia of the esophagus (BE) is the precursor lesion of esophageal
adenocarcinoma (EAC), a deadly disease with a 5-year overall survival of less than 20 …

Bile acid at low pH reduces squamous differentiation and activates EGFR signaling in esophageal squamous cells in 3-D culture

S Ghatak, M Reveiller, L Toia, A Ivanov… - Journal of …, 2013 - Springer
Background Barrett's esophagus is a preneoplastic metaplasia in which the normal
squamous epithelium of the esophagus changes to an intestinal, columnar phenotype due …

HIDA and seek: challenges of scintigraphy to diagnose bile reflux post-bariatric surgery

TA Eldredge, M Bills, JC Myers, D Bartholomeusz… - Obesity surgery, 2020 - Springer
Introduction Oesophageal bile reflux after bariatric surgery may trigger development of
Barrett's oesophagus. Gastro-oesophageal reflux of bile is captured by hepatobiliary …