The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …

To survive, cancer cells must resist numerous internal and environmental insults associated
with neoplasia that jeopardize proteostasis within the endoplasmic reticulum (ER). Solid and …

A central mechanism regulating translation initiation in response to environmental stress
involves phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) …

The unfolded protein response (UPR) is a highly conserved pathway that allows the cell to
manage endoplasmic reticulum (ER) stress that is imposed by the secretory demands …

Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

Translation regulation largely occurs during initiation, which features ribosome assembly
onto mRNAs and selection of the translation start site. Short, upstream ORFs (uORFs) …

The endoplasmic reticulum (ER) responds to the accumulation of unfolded proteins in its
lumen (ER stress) by activating intracellular signal transduction pathways—cumulatively …

The endoplasmic reticulum (ER) is the largest intracellular organelle carrying out a broad
range of important cellular functions including protein biosynthesis, folding, and trafficking …

Unfolded and malfolded client proteins impose a stress on the endoplasmic reticulum (ER),
which contributes to cell death in pathophysiological conditions. The transcription factor …

In response to environmental stresses, a family of protein kinases phosphorylate eIF2
(eukaryotic initiation factor 2) to alleviate cellular injury or alternatively induce apoptosis …