Genetics of bipolar disorder
N Craddock, P Sklar - The Lancet, 2013 - thelancet.com
Studies of families and twins show the importance of genetic factors affecting susceptibility to
bipolar disorder and suggest substantial genetic and phenotypic complexity. Robust and …
bipolar disorder and suggest substantial genetic and phenotypic complexity. Robust and …
Cognitive dysfunction in unipolar depression: implications for treatment
MH Trivedi, TL Greer - Journal of affective disorders, 2014 - Elsevier
Objective The primary objective of this review is to examine the literature assessing
abnormalities in neural circuitry and cognition early in the course of major depressive …
abnormalities in neural circuitry and cognition early in the course of major depressive …
GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
JW Trampush, MLZ Yang, J Yu, E Knowles… - Molecular …, 2017 - nature.com
The complex nature of human cognition has resulted in cognitive genomics lagging behind
many other fields in terms of gene discovery using genome-wide association study (GWAS) …
many other fields in terms of gene discovery using genome-wide association study (GWAS) …
Executive function impairments in depression and bipolar disorder: association with functional impairment and quality of life
Background The neuropsychological correlates of major depressive (MDD) and bipolar
disorder (BD), and their association with quality of life (QOL) and functioning, have not been …
disorder (BD), and their association with quality of life (QOL) and functioning, have not been …
Empirical evidence for discrete neurocognitive subgroups in bipolar disorder: clinical implications
KE Burdick, M Russo, S Frangou, K Mahon… - Psychological …, 2014 - cambridge.org
BackgroundRecent data suggest trait-like neurocognitive impairments in bipolar disorder
(BPD), with deficits about 1 sd below average, less severe than deficits noted in …
(BPD), with deficits about 1 sd below average, less severe than deficits noted in …
Cognitive impairment in schizophrenia
Cognitive functioning is moderately to severely impaired in patients with schizophrenia. This
impairment is the prime driver of the significant disabilities in occupational, social, and …
impairment is the prime driver of the significant disabilities in occupational, social, and …
Methodological recommendations for cognition trials in bipolar disorder by the International Society for Bipolar Disorders Targeting Cognition Task Force
Objectives To aid the development of treatment for cognitive impairment in bipolar disorder,
the International Society for Bipolar Disorders (ISBD) convened a task force to create a …
the International Society for Bipolar Disorders (ISBD) convened a task force to create a …
Characterizing cognitive heterogeneity on the schizophrenia–bipolar disorder spectrum
Background Current group-average analysis suggests quantitative but not qualitative
cognitive differences between schizophrenia (SZ) and bipolar disorder (BD). There is …
cognitive differences between schizophrenia (SZ) and bipolar disorder (BD). There is …
Social and nonsocial cognition in bipolar disorder and schizophrenia: relative levels of impairment
Objective This study aimed to determine the relative extent of impairment in social and
nonsocial cognitive domains in patients with bipolar disorder compared with schizophrenia …
nonsocial cognitive domains in patients with bipolar disorder compared with schizophrenia …
Large-scale cognitive GWAS meta-analysis reveals tissue-specific neural expression and potential nootropic drug targets
Here, we present a large (n= 107,207) genome-wide association study (GWAS) of general
cognitive ability (" g"), further enhanced by combining results with a large-scale GWAS of …
cognitive ability (" g"), further enhanced by combining results with a large-scale GWAS of …