Nonsocial and social cognition in schizophrenia: current evidence and future directions
Cognitive impairment in schizophrenia involves a broad array of nonsocial and social
cognitive domains. It is a core feature of the illness, and one with substantial implications for …
cognitive domains. It is a core feature of the illness, and one with substantial implications for …
Mechanisms underlying dorsolateral prefrontal cortex contributions to cognitive dysfunction in schizophrenia
Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …
Immediate early genes, memory and psychiatric disorders: focus on c-Fos, Egr1 and Arc
Many psychiatric disorders, despite their specific characteristics, share deficits in the
cognitive domain including executive functions, emotional control and memory. However …
cognitive domain including executive functions, emotional control and memory. However …
Memory and cognition in schizophrenia
Episodic memory deficits are consistently documented as a core aspect of cognitive
dysfunction in schizophrenia patients, present from the onset of the illness and strongly …
dysfunction in schizophrenia patients, present from the onset of the illness and strongly …
The regulatory role of the human mediodorsal thalamus
The function of the human mediodorsal thalamic nucleus (MD) has so far eluded a clear
definition in terms of specific cognitive processes and tasks. Although it was at first proposed …
definition in terms of specific cognitive processes and tasks. Although it was at first proposed …
Exercise intervention in individuals at clinical high risk for psychosis: benefits to fitness, symptoms, hippocampal volumes, and functional connectivity
Abstract Background and Hypothesis Individuals at clinical high risk for psychosis (CHR-p)
are less fit than nonclinical peers and show hippocampal abnormalities that relate to clinical …
are less fit than nonclinical peers and show hippocampal abnormalities that relate to clinical …
Normalization of mediotemporal and prefrontal activity, and mediotemporal-striatal connectivity, may underlie antipsychotic effects of cannabidiol in psychosis
A O'Neill, R Wilson, G Blest-Hopley… - Psychological …, 2021 - cambridge.org
BackgroundRecent evidence suggests that cannabidiol (CBD), a non-intoxicating ingredient
present in cannabis extract, has an antipsychotic effect in people with established psychosis …
present in cannabis extract, has an antipsychotic effect in people with established psychosis …
MicroRNAs in the Onset of Schizophrenia
KT Thomas, SS Zakharenko - Cells, 2021 - mdpi.com
Mounting evidence implicates microRNAs (miRNAs) in the pathology of schizophrenia.
These small noncoding RNAs bind to mRNAs containing complementary sequences and …
These small noncoding RNAs bind to mRNAs containing complementary sequences and …
Utility of imaging-based biomarkers for glutamate-targeted drug development in psychotic disorders: a randomized clinical trial
Importance Despite strong theoretical rationale and preclinical evidence, several glutamate-
targeted treatments for schizophrenia have failed in recent pivotal trials, prompting questions …
targeted treatments for schizophrenia have failed in recent pivotal trials, prompting questions …
Impaired theta phase coupling underlies frontotemporal dysconnectivity in schizophrenia
Frontotemporal dysconnectivity is a key pathology in schizophrenia. The specific nature of
this dysconnectivity is unknown, but animal models imply dysfunctional theta phase coupling …
this dysconnectivity is unknown, but animal models imply dysfunctional theta phase coupling …